ArticleHeart failure reviews2011
Innate immunity and remodelling.
Article in Heart failure reviews, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed.
- Microvesicle-Shuttled microRNA-130b Activates the Hepatic Inflammation by Inhibiting Glucocorticoid-Receptor-Mediated Immunosuppression in High-Fat Diet-Induced Obese Mice.Veterinary sciences · 2024Article
- Review
- Exercise Training after Myocardial Infarction Attenuates Dysfunctional Ventricular Remodeling and Promotes Cardiac Recovery.Reviews in cardiovascular medicine · 2022Review
- Various aspects of inflammation in heart failure.Heart failure reviews · 2020Review
- Tumor Necrosis Factor-α in Heart Failure: an Updated Review.Current cardiology reports · 2018Review
- Murine Myocardial Transcriptome Analysis Reveals a Critical Role of COPS8 in the Gene Expression of Cullin-RING Ligase Substrate Receptors and Redox and Vesicle Trafficking Pathways.Frontiers in physiology · 2017Article
- Evaluation of Innate Immunity Biomarkers on Admission and at Discharge From an Acute Heart Failure Episode.Journal of clinical laboratory analysis · 2016Observational
- The role of nitric oxide in regulation of leukocyte migration into the heart tissue in vitro.Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections · 2015Article
- Angiotensin Ⅱ Activates MCP-1 and Induces Cardiac Hypertrophy and Dysfunction via Toll-like Receptor 4.Journal of atherosclerosis and thrombosis · 2015Article
- Pathophysiology of sepsis-related cardiac dysfunction: driven by inflammation, energy mismanagement, or both?Current heart failure reports · 2015Review
- Diacerein improves left ventricular remodeling and cardiac function by reducing the inflammatory response after myocardial infarction.PloS one · 2015Article
- Cardiomyocyte p65 nuclear factor-κB is necessary for compensatory adaptation to pressure overload.Circulation. Heart failure · 2015Article
- Relationship of TLR2, TLR4 and tissue remodeling in chronic rhinosinusitis.International journal of clinical and experimental pathology · 2015Article
- Protein kinase Cε-calcineurin cosignaling downstream of toll-like receptor 4 downregulates fibrosis and induces wound healing gene expression in cardiac myofibroblasts.Molecular and cellular biology · 2014Article
- Cardiomyocyte-specific p65 NF-κB deletion protects the injured heart by preservation of calcium handling.American journal of physiology. Heart and circulatory physiology · 2013Article
- Article
- Inhibitory kappa-B kinase-β inhibition prevents adaptive left ventricular hypertrophy.The Journal of surgical research · 2012Article
- Overexpression of angiopoietin-1 reduces doxorubicin-induced apoptosis in cardiomyocytes.Journal of biomedical research · 2012Article
- Combined deep microRNA and mRNA sequencing identifies protective transcriptomal signature of enhanced PI3Kα signaling in cardiac hypertrophy.Journal of molecular and cellular cardiology · 2012Article
Corrections and comments
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A wide variety of cardiac disease states can induce remodelling and lead to the functional consequence of heart failure. These complex disease states involve a plethora of parallel signal transduction events, which may be associated with tissue injury or tissue repair. Innate immunity is activated in hearts injured in different ways, evident as cytokine release from the heart, activation of toll-like receptors involved in recognizing danger, and activation of the transcription factor nuclear factor kappa B. Nuclear factor kappa B regulates gene programmes involved in inflammation as well as the resolution of inflammation. The impact of this is an enigma; while cytokines, toll-like receptors, and nuclear factor kappa B appear to elicit myocardial protection in studies of preconditioning, the literature strongly indicates a detrimental role for activation of innate immunity in studies of acute ischaemia-reperfusion injury. The impact of activation of cardiac innate immunity on the long-term outcome in in vivo models of hypertrophy and remodelling is less clear, with conflicting results as to whether it is beneficial or detrimental. More research using genetically engineered mice as tools, different models of evoking remodelling, and long-term follow-up is required for us to conclude whether activation of the innate immune system is good, bad, or unimportant in chronic injury models.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.