ArticleSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2010
Clinical use of oral laxatives in palliative care services in Spain.
Article in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed, 2 syntheses or guidelines pooled it, 11 citations in OpenAlex.
- MASCC recommendations on the management of constipation in patients with advanced cancer.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2020Guideline
- Laxatives for the management of constipation in people receiving palliative care.The Cochrane database of systematic reviews · 2015Pooled it
- Laxative prescriptions to cancer outpatients receiving opioids: a study from the Norwegian prescription database.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2013Article
Corrections and comments
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Authors and funding
4 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThis study was aimed at evaluating the clinical use of laxatives in palliative care treatment, their overall effectiveness, and their relationship to opioid treatment. POPULATION AND
methodA cross-sectional prospective study on patients attended by 21 palliative care teams on two pre-determined dates was carried out. The variables analyzed were demographic data, underlying disease, functional status, laxative use, use of enemas, concomitant opioid medication, and bowel movements.
resultsOf the 283 patients studied, 54 (19%) have had three or fewer bowel movements per week in the 3 weeks prior to the study, 53 patients (19%) were using rectal measures, 177 patients (63%) were being treated with opioids, and 164 patients (58%) were taking laxatives. Sixty seven percent (119/177) of the patients being treated with opioids were also being treated with laxatives, as were 43% (45/106) of those not receiving opioid treatment. The laxative most used was lactulose (65%). Only 10% used the most recommended combination of an osmotic or softener laxative mixed with another stimulant laxative. Some 24% of patients used enemas or micro enemas in addition to laxatives, 14 patients treated their constipation without laxatives, using only rectal measures.
conclusionThe clinical practice of the use of oral laxatives in palliative care in our environment differs widely from that recommended in the literature. Further studies are required to confirm if a revision of clinical guidelines are required.
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