ReviewCerebellum (London, England)2012
Purinergic modulation of granule cells.
Review in Cerebellum (London, England), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed, 9 citations in OpenAlex.
- Neuroprotection Mediated by P2Y13 Nucleotide Receptors in Neurons.Computational and structural biotechnology journal · 2015Review
- Presynaptic adenosine A₁ receptors modulate excitatory transmission in the rat basolateral amygdala.Neuropharmacology · 2014Article
- Diversity and complexity of roles of granule cells in the cerebellar cortex. Editorial.Cerebellum (London, England) · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Extracellular purines exert their action in the nervous system through purinergic neurotransmission and neuromodulatory processes. Among brain areas, efforts have been made to investigate the purinergic modulation of the cerebellar cortex. In addition, the use of granule cells in culture as a neuronal in vitro model provided important information about the implications of purines in mechanisms such as cell survival and differentiation. This short review is focused on the function of purines in the physiology of granule cells in situ and in vitro. In situ, adenosine has been shown to inhibit some of the glutamatergic and GABAergic synaptic inputs to granule cells. The inhibition of GABA input allows an increase in the excitability of the cell while the output (parallel fibers) of granule cells is also down-regulated by adenosine, suggesting a complex mode of regulation by purines. In vitro, granule cells have been shown to express members of all classes of purinergic receptors, P2X (ionotropic), P2Y (metabotropic) and adenosine receptors. The specific expression of these receptors and the downstream signaling pathways coupling them to cell survival and growth have been extensively studied.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.