ArticleAAPS PharmSciTech2010
Formulation of dacarbazine-loaded cubosomes. Part III. Physicochemical characterization.
Article in AAPS PharmSciTech, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 59 citations in OpenAlex.
- Potential combination topical therapy of anal fissure: development, evaluation, and clinical study†.Drug delivery · 2018Trial
- Cilnidipine Cubosomal Nanogel Patch: Polymer-Nanostructure Synergy for Advanced Transdermal Drug Delivery.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Detailed Comprehensive Review on Advancement of Cubosomes and their Currently Available Applications.Current pharmaceutical biotechnology · 2026Review
- The ultrasound wave enhanced carbon nanotube encapsulated dacarbazine effect on melanoma cell death via ER stress-mediated apoptosis.Journal of education and health promotion · 2026Article
- Design, synthesis of some novel coumarins and their nanoformulations into lipid-chitosan nanocapsule as unique antimicrobial agents.Scientific reports · 2024Article
- Synthesis of eco-friendly layered double hydroxide and nanoemulsion for jasmine and peppermint oils and their larvicidal activities against Culex pipiens Linnaeus.Scientific reports · 2024Article
- Optimization of hyaluronan-enriched cubosomes for bromfenac delivery enhancing corneal permeation: characterization, ex vivo, and in vivo evaluation.Drug delivery · 2023Article
- Cubic nanoparticles as potential carriers for a natural anticancer drug: development, in vitro and in vivo characterization.Drug delivery and translational research · 2023Article
- Travoprost Liquid Nanocrystals: An Innovative Armamentarium for Effective Glaucoma Therapy.Pharmaceutics · 2023Article
- Optimizing Dacarbazine Therapy: Design of a Laser-Triggered Delivery System Based on β-Cyclodextrin and Plasmonic Gold Nanoparticles.Pharmaceutics · 2023Article
- pH-Responsive Hybrid Nanoassemblies for Cancer Treatment: Formulation Development, Optimization, and In Vitro Therapeutic Performance.Pharmaceutics · 2023Article
- Preclinical assessment of nanostructured liquid crystalline particles for the management of bacterial keratitis: in vivo and pharmacokinetics study.Drug delivery and translational research · 2022Article
- Ion exchange column technique as a novel method for evaluating the release of docetaxel from different lipid nanoparticles.Drug delivery and translational research · 2022Article
- Encapsulation of Cancer Therapeutic Agent Dacarbazine Using Nanostructured Lipid Carrier.Journal of visualized experiments : JoVE · 2016Article
- In vitro and in vivo evaluation of cubosomes containing 5-fluorouracil for liver targeting.Acta pharmaceutica Sinica. B · 2015Article
- Nanotechnology-Based Drug Delivery Systems for Melanoma Antitumoral Therapy: A Review.BioMed research international · 2015Review
- Treatment of cutaneous candidiasis through fluconazole encapsulated cubosomes.Drug delivery and translational research · 2014Article
- Engineering nanomedicines for improved melanoma therapy: progress and promises.Nanomedicine (London, England) · 2010Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The purpose of this study was to investigate the physicochemical properties of dacarbazine-loaded cubosomes. The drug-loaded cubosome nanocarriers were prepared by a fragmentation method and then freeze dried. They were then characterized for size, morphology, thermal behavior, and crystallography using dynamic light scattering, transmission electron microscopy (TEM), differential scanning calorimetry (DSC), and powder X-ray diffraction (PXRD), respectively. The drug loading and encapsulation efficiency were determined by UV spectrophotometry. The results showed that the prepared dacarbazine-loaded cubosomes had mean diameters ranging from 86 to 106 nm. In addition to the TEM, the characteristic peaks from PXRD data suggested that the freeze-dried nanoformulations were indeed cubic in nature. DSC and PXRD analysis suggested the 0.06 or 0.28% w/w actual drug loaded inside cubosomes was in the amorphous or molecular state. These physicochemical characteristics would affect the nanoformulation shelf-life, efficacy, and safety.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.