ArticleEuropean journal of clinical pharmacology2010
Appropriateness of treatment recommendations for PPI in hospital discharge letters.
Article in European journal of clinical pharmacology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 3 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
32 citing papers in PubMed, 3 syntheses or guidelines pooled it, 87 citations in OpenAlex.
- Proton pump inhibitor use increases hepatic encephalopathy risk: A systematic review and meta-analysis.World journal of gastroenterology · 2019Pooled it
- Effectiveness of Interventions to Deprescribe Inappropriate Proton Pump Inhibitors in Older Adults.Drugs & aging · 2017Pooled it
- Pooled it
- Comparison of Tegoprazan and Lansoprazole in Patients With Erosive Esophagitis up to 4 Weeks: A Multi-Center, Randomized, Double-Blind, Active-Comparator Phase 4 Trial.Neurogastroenterology and motility · 2025Trial
- Gaviscon® vs. omeprazole in symptomatic treatment of moderate gastroesophageal reflux. a direct comparative randomised trial.BMC gastroenterology · 2012Trial
- Proton pump inhibitors and 1-year risk of adverse outcomes after discharge from internal medicine wards: an observational study in the REPOSI cohort.Internal and emergency medicine · 2025Observational
- Proton pump inhibitor use is associated with increased liver steatosis.Biomedical reports · 2024Article
- The Impact of Sex on the Response to Proton Pump Inhibitor Treatment.Pharmaceuticals (Basel, Switzerland) · 2023Review
- Association between hospital-acquired pneumonia and proton pump inhibitor prophylaxis in patients treated with glucocorticoids: a retrospective cohort study based on 307,622 admissions in China.Journal of thoracic disease · 2022Article
- The efficacy and safety of the short-term combination therapy with ticagrelor and PPIs or H2RA in patients with acute STEMI who underwent emergency PCI.Clinical and translational science · 2022Article
- Review
- Effects of the Long-term Treatment of Proton Pump Inhibitors on the Function of Kidney and Liver in Laboratory Female Rats.Archives of Razi Institute · 2021Article
- A Cross-Sectional Study on Single-Day Use of Proton Pump Inhibitors in Tertiary Care Hospitals of South India.Hospital pharmacy · 2021Article
- Proton pump inhibitors and the risk of hospital-acquired acute kidney injury in children.Annals of translational medicine · 2020Article
- The analysis of the use of potentially inappropriate medications in elderly in the Slovak Republic.International journal of clinical pharmacy · 2020Article
- The inappropriate use of proton pump inhibitors during admission and after discharge: a prospective cross-sectional study.International journal of clinical pharmacy · 2020Observational
- Educational Intervention Improves Proton Pump Inhibitor Stewardship in Outpatient Gastroenterology Clinics.Gastroenterology research · 2019Article
- Problems Associated with Deprescribing of Proton Pump Inhibitors.International journal of molecular sciences · 2019Review
- Prescription Pattern of Proton Pump Inhibitors at Hospital Admission and Discharge.GE Portuguese journal of gastroenterology · 2019Article
- The Dark Side of the Long-Term Use of Proton Pump Inhibitors in Chronic Liver Disease.GE Portuguese journal of gastroenterology · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe reasons for the dramatic increase in proton pump inhibitors (PPI) prescriptions remain unclear and cannot be explained solely by increased morbidity, new indications or a decrease in alternative medication. Inappropriate use and discharge recommendations in hospitals are considered to be possible explanations. As the quality of PPI recommendations in hospital discharge letters in Germany has not been investigated to date, we have studied the appropriateness of these referrals.
methodsHospital discharge letters with recommendations for PPI medication from 35 primary care practices in the county of Mecklenburg-Western Pomerania (MV; North-east Germany) were collected and analysed, and the appropriateness of the PPI indication was rated.
resultsNo information justifying the recommendation for continuous PPI medication could be identified in 54.5% of the discharge letters; in 12.7%, the indication was uncertain, and in 32.7%, we found an evidence-based indication for PPI medication. The most common indication for adequate PPI use was nonsteroidal anti-inflammatory drug-prophylaxis in high-risk patients.
conclusionsInadequate recommendations for PPIs in discharge letters are frequent. This may lead to a continuation of this therapy in primary care, thereby unnecessarily increasing polypharmacy and the risk of adverse events as well as burdening the public health budget. Hospitals should therefore critically review recommendations for PPI medication and the dosage thereof in their discharge letters and clearly document the reason for PPI use and the need for continuous prescription in primary care.
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