ArticleChemical communications (Cambridge, England)2010
Excursions in polynuclear platinum DNA binding.
Article in Chemical communications (Cambridge, England), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
32 citing papers in PubMed, 109 citations in OpenAlex.
- Carrier-free prodrug nanoparticles based on dasatinib and cisplatin for efficient antitumorAsian journal of pharmaceutical sciences · 2021Article
- Conformational Modulation of Iduronic Acid-Containing Sulfated Glycosaminoglycans by a Polynuclear Platinum Compound and Implications for Development of Antimetastatic Platinum Drugs.Angewandte Chemie (International ed. in English) · 2021Article
- Synthesis of Platinum(II) Complexes with Some 1-Methylnitropyrazoles and In Vitro Research on Their Cytotoxic Activity.Pharmaceuticals (Basel, Switzerland) · 2020Article
- Directing Quinone Methide-Dependent Alkylation and Cross-Linking of Nucleic Acids with Quaternary Amines.Bioconjugate chemistry · 2020Article
- From Interaction to Function in DNA-Templated Supramolecular Self-Assemblies.ChemistryOpen · 2020Review
- Molecular methods for assessment of non-covalent metallodrug-DNA interactions.Chemical Society reviews · 2019Review
- Elucidation of the Mechanism of Action for Metal Based Anticancer Drugs by Mass Spectrometry-Based Quantitative Proteomics.Molecules (Basel, Switzerland) · 2019Review
- TriplatinNC and Biomolecules: Building Models Based on Non-covalent Interactions.Frontiers in chemistry · 2019Article
- Inhibition of nuclear factor kappaB proteins-platinated DNA interactions correlates with cytotoxic effectiveness of the platinum complexes.Scientific reports · 2016Article
- Geometry matters: inverse cytotoxic relationship for cis/trans-Ru(ii) polypyridyl complexes from cis/trans-[PtCl2(NH3)2].Chemical communications (Cambridge, England) · 2016Article
- The Next Generation of Platinum Drugs: Targeted Pt(II) Agents, Nanoparticle Delivery, and Pt(IV) Prodrugs.Chemical reviews · 2016Review
- Competitive formation of DNA linkage isomers by a trinuclear platinum complex and the influence of pre-association.Dalton transactions (Cambridge, England : 2003) · 2015Article
- Solution studies on DNA interactions of substitution-inert platinum complexes mediated via the phosphate clamp.Dalton transactions (Cambridge, England : 2003) · 2015Article
- Nucleolar targeting by platinum: p53-independent apoptosis follows rRNA inhibition, cell-cycle arrest, and DNA compaction.Molecular pharmaceutics · 2015Article
- The phosphate clamp: sequence selective nucleic acid binding profiles and conformational induction of endonuclease inhibition by cationic Triplatin complexes.Nucleic acids research · 2014Article
- Substitution-inert trinuclear platinum complexes efficiently condense/aggregate nucleic acids and inhibit enzymatic activity.Angewandte Chemie (International ed. in English) · 2014Article
- Cytotoxic efficacy of a novel dinuclear platinum(II) complex used with anti-MUC1 in human breast cancer cells.Molecular and cellular biochemistry · 2014Article
- Synthetic methods for the preparation of platinum anticancer complexes.Chemical reviews · 2014Review
- A new approach to glycan targeting: enzyme inhibition by oligosaccharide metalloshielding.Chemical communications (Cambridge, England) · 2014Article
- Differentiation and distributions of DNA/cisplatin crosslinks by liquid chromatography-electrospray ionization-infrared multiphoton dissociation mass spectrometry.Journal of the American Society for Mass Spectrometry · 2014Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Polynuclear platinum agents are a structurally unique class of anti-cancer drugs, distinct from the cisplatin family. To describe the chemistry and biology of this class, it was necessary to challenge the accepted paradigms for the structure-activity relationships; design new chemotypes and delineate the structures and consequences of their DNA binding modes. This article summarizes the structural changes induced in DNA by both covalent (bond-forming) and non-covalent (ligand recognition) adducts. Solution (Nuclear Magnetic Resonance), solid state (crystallography) and gas-phase (Electrospray Ionization Mass Spectrometry) techniques have all been used to describe the new DNA structures along with molecular biological techniques. The combined approaches allow molecular description of hitherto unobserved adducts such as long-range major-groove interstrand crosslinks; directional isomers on DNA and a third class of ligand-DNA binding, the phosphate clamp. The phosphate recognition is distinct from ''classic'' minor-groove recognition or intercalation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.