ArticlePrimary care companion to the Journal of clinical psychiatry2010
The effect of antipsychotic medication on neuromotor abnormalities in neuroleptic-naive nonaffective psychotic patients: a naturalistic study with haloperidol, risperidone, or olanzapine.
Article in Primary care companion to the Journal of clinical psychiatry, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.
- [The sensorimotor domain in the research domain criteria system: progress and perspectives].Der Nervenarzt · 2021Pooled it
- Clinical and neurobiological correlates of tardive dyskinesia in schizophrenia spectrum disorders and mood disorders.Schizophrenia (Heidelberg, Germany) · 2026Article
- Obsessive-compulsive and catatonic symptoms in the early stages of psychosis: Are they related?European archives of psychiatry and clinical neuroscience · 2025Article
- Gait Disturbance in Patients with Schizophrenia in Relation to Walking Speed, Ankle Joint Range of Motion, Body Composition, and Extrapyramidal Symptoms.Healthcare (Basel, Switzerland) · 2025Article
- Multidimensional outcome of first-episode psychosis: a network analysis.Psychological medicine · 2025Article
- Psychomotor slowing alters gait velocity, cadence, and stride length and indicates negative symptom severity in psychosis.Schizophrenia (Heidelberg, Germany) · 2022Article
- Extrapyramidal symptoms predict cognitive performance after first-episode psychosis.Schizophrenia (Heidelberg, Germany) · 2022Article
- Motor Behavior is Relevant for Understanding Mechanism, Bolstering Prediction, And Improving Treatment: A Transdiagnostic Perspective.Schizophrenia bulletin · 2022Article
- Low physical activity is associated with two hypokinetic motor abnormalities in psychosis.Journal of psychiatric research · 2022Article
- Validation of the Apraxia Screen TULIA (AST) in Schizophrenia.Neuropsychobiology · 2022Article
- Extrapyramidal side effects in first-episode schizophrenia treated with flupenthixol decanoate.The South African journal of psychiatry : SAJP : the journal of the Society of Psychiatrists of South Africa · 2021Article
- Cerebellar-cortical dysconnectivity in resting-state associated with sensorimotor tasks in schizophrenia.Human brain mapping · 2020Article
- Effects of different types of sensory signals on reaching performance in persons with chronic schizophrenia.PloS one · 2020Article
- Using Virtual Reality as a Tool in the Rehabilitation of Movement Abnormalities in Schizophrenia.Frontiers in psychology · 2020Article
- Aberrant Middle Prefrontal-Motor Cortex Connectivity Mediates Motor Inhibitory Biomarker in Schizophrenia.Biological psychiatry · 2019Article
- Tardive Dyskinesia Associated with Atypical Antipsychotics: Prevalence, Mechanisms and Management Strategies.CNS drugs · 2018Review
- Distinct Associations of Motor Domains in Relatives of Schizophrenia Patients-Different Pathways to Motor Abnormalities in Schizophrenia?Frontiers in psychiatry · 2018Article
- Aberrant Hyperconnectivity in the Motor System at Rest Is Linked to Motor Abnormalities in Schizophrenia Spectrum Disorders.Schizophrenia bulletin · 2017Article
- Motor Abnormalities: From Neurodevelopmental to Neurodegenerative Through "Functional" (Neuro)Psychiatric Disorders.Schizophrenia bulletin · 2017Review
- Aberrant Force Processing in Schizophrenia.Schizophrenia bulletin · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo examine the effect of antipsychotic medication on neuromotor abnormalities in a sample of psychotic patients never exposed to antipsychotic drugs.
methodOne hundred psychotic patients were assessed (from January 1998 to December 2002) using DSM-IV criteria for parkinsonism, dyskinesia, akathisia, catatonia, and dystonia at baseline and after 4 weeks of treatment with haloperidol (n = 23), risperidone (n = 52), or olanzapine (n = 25). We examined change scores in neuromotor ratings over the treatment period across treatment groups and rates of drug-responsive and drug-emergent neuromotor syndromes in patients with and without preexisting neuromotor abnormalities.
resultsOverall time effects revealed a worsening of parkinsonism (P = .002) and akathisia (P = .002) ratings and an improvement of dyskinesia (P = .001) and catatonia (P < .001) ratings. Main treatment effects revealed that patients taking haloperidol had a significant mean increase in akathisia scores compared with those of patients taking risperidone (P = .002) or olanzapine (P < .001). A significantly greater percentage of olanzapine-treated patients experienced remission of preexisting parkinsonism than did the other treatment groups (P = .047). Patients without preexisting motor abnormalities were more likely to experience drug-emergent parkinsonism if they were treated with haloperidol or risperidone than with olanzapine (P = .001) and were more likely to experience drug-emergent dystonia (P = .014) and akathisia (P = .013) if they were treated with haloperidol than with risperidone or olanzapine.
conclusionsThe relationship between antipsychotic medication and neurologic abnormalities is more complex than previously acknowledged since antipsychotic drugs may both improve preexisting abnormalities and cause "de novo" neurologic syndromes. Overall, olanzapine has a more favorable neuromotor profile than risperidone, which in turn has a more favorable profile than haloperidol.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.