Evidence map›Paper›PMID 20693843›Full record

ReviewCancer journal (Sudbury, Mass.)

Chemokines: can effector cells be redirected to the site of the tumor?

Steven M Dubinett, Jay M Lee, Sherven Sharma, James J Mulé

Open access · greenAbstract readReview
In one paragraph

Review in Cancer journal (Sudbury, Mass.). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 40 citations in OpenAlex.

  1. Article
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  8. Nanoformulation of CCL21 greatly increases its effectiveness as an immunotherapy for neuroblastoma.Journal of controlled release : official journal of the Controlled Release Society · 2020
    Article
  9. Article
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  11. Phase I Trial of Intratumoral Injection ofClinical cancer research : an official journal of the American Association for Cancer Research · 2017
    Article
  12. Article
  13. Article
  14. Review
  15. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Steven M DubinettDepartment of Medicine, University of California Los Angeles Lung Cancer Research Program, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.
Jay M Lee
Sherven Sharma
James J Mulé
University of California, Los Angeles · US

Funding

Designing Lymph Nodes for Cancer ImmunotherapyR01CA148995 · NCI · H. LEE MOFFITT CANCER CTR & RES INST · PI MULE, JAMES J. · 2010 to 2014
$1.7M
Gene Modified Dendritic Cell Therapy in Lung CancerK23CA131577 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LEE, JAY M · 2009 to 2013
$660k
NCI NIH HHS K23 CA131577NCI NIH HHS R01 CA148995
6 · The paper itself

Abstract

Chemokines (ie, chemoattractant cytokines) are a family of small secreted molecules that mediate leukocyte migration. It is becoming increasingly more evident that chemokines play an integral role in the initiation of a specific immune response. With respect to cancer, chemokines are being studied for both their role in tumor biology and as promising immunotherapy candidates. We review several areas of chemokine importance in tumor immunity and discuss the experimental evidence that is leading to the clinical use of this cytokine family in new treatment approaches for patients with cancer.

Indexed as

AnimalsChemokinesHumansNeoplasmsReceptors, ChemokineChemokinesReceptors, Chemokine

Identifiers

PMID20693843
PMCPMC3076643
OpenAlexW1993008395

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.