ArticleApplied and environmental microbiology2010
Exploring mechanisms of resistance to respiratory inhibitors in field strains of Botrytis cinerea, the causal agent of gray mold.
Article in Applied and environmental microbiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
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52 citing papers in PubMed, 270 citations in OpenAlex.
- Prevalence of Quinone Outside Inhibitor Fungicide Resistance and Dynamics of Cytochrome b Genotypes Under Different Fungicide Selection Pressure in Botrytis cinerea Isolates from Korean Strawberry Farms.The plant pathology journal · 2026Article
- Simultaneous detection of multiple sdhB SNPs in Botrytis cinerea using a universal quenching probe-based LAMP assay.Analytical sciences : the international journal of the Japan Society for Analytical Chemistry · 2026Article
- Virulence Profiles and Fungicide-Target-Gene Variability inJournal of fungi (Basel, Switzerland) · 2026Article
- Antifungal Activity ofMicroorganisms · 2026Article
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- BcatrB mediates pyrimethanil resistance in Botrytis cinerea revealed by transcriptomics analysis.Scientific reports · 2025Article
- Baseline Sensitivity of Botryosphaeria spp. Isolated from Apples to Pyraclostrobin in Korea.The plant pathology journal · 2025Article
- Synthetic and Natural Antifungal Substances in Cereal Grain Protection: A Review of Bright and Dark Sides.Molecules (Basel, Switzerland) · 2024Review
- Procymidone Application Contributes to Multidrug Resistance ofJournal of fungi (Basel, Switzerland) · 2024Article
- Genotypic and phenotypic characterization of resistance to fenhexamid, carboxin, and, prochloraz, inFrontiers in microbiology · 2024Article
- Identification of Fungicide Combinations for OvercomingMicroorganisms · 2023Article
- Fungicide Resistance inBiotech (Basel (Switzerland)) · 2023Review
- Identification of sequence mutations in Phytophthora cactorum genome associated with mefenoxam resistance and development of a molecular assay for the mutant detection in strawberry (F. × ananassa).Scientific reports · 2023Article
- Antifungal Activity of 2-Allylphenol Derivatives on theInternational journal of molecular sciences · 2023Article
- Multiple and multidrug resistance inFrontiers in plant science · 2023Article
- Do mitochondria use efflux pumps to protect their ribosomes from antibiotics?Microbiology (Reading, England) · 2023Article
- Mechanism of Pydiflumetofen Resistance inJournal of fungi (Basel, Switzerland) · 2022Article
- Molecular identification and characterization ofCurrent research in microbial sciences · 2021Article
- Characterization of the Fungitoxic Activity onJournal of fungi (Basel, Switzerland) · 2021Article
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Respiratory inhibitors are among the fungicides most widely used for disease control on crops. Most are strobilurins and carboxamides, inhibiting the cytochrome b of mitochondrial complex III and the succinate dehydrogenase of mitochondrial complex II, respectively. A few years after the approval of these inhibitors for use on grapevines, field isolates of Botrytis cinerea, the causal agent of gray mold, resistant to one or both of these classes of fungicide were recovered in France and Germany. However, little was known about the mechanisms underlying this resistance in field populations of this fungus. Such knowledge could facilitate resistance risk assessment. The aim of this study was to investigate the mechanisms of resistance occurring in B. cinerea populations. Highly specific resistance to strobilurins was correlated with a single mutation of the cytb target gene. Changes in its intronic structure may also have occurred due to an evolutionary process controlling selection for resistance. Specific resistance to carboxamides was identified for six phenotypes, with various patterns of resistance levels and cross-resistance. Several mutations specific to B. cinerea were identified within the sdhB and sdhD genes encoding the iron-sulfur protein and an anchor protein of the succinate dehydrogenase complex. Another as-yet-uncharacterized mechanism of resistance was also recorded. In addition to target site resistance mechanisms, multidrug resistance, linked to the overexpression of membrane transporters, was identified in strains with low to moderate resistance to several respiratory inhibitors. This diversity of resistance mechanisms makes resistance management difficult and must be taken into account when developing strategies for Botrytis control.
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