ArticleDiabetes2010
Liver fat content in type 2 diabetes: relationship with hepatic perfusion and substrate metabolism.
Article in Diabetes, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Compartmental modeling for blood flow quantification from dynamicAnnals of nuclear medicine · 2025Pooled it
- Effects of short-term sprint interval and moderate-intensity continuous training on liver fat content, lipoprotein profile, and substrate uptake: a randomized trial.Journal of applied physiology (Bethesda, Md. : 1985) · 2019Trial
- Evaluation of liver perfusion in diabetic patients using 99mTc-sestamibi.Wiener klinische Wochenschrift · 2015Trial
- New compartment model for hepatic blood flow quantification in humans from 15O-water PET images.European journal of nuclear medicine and molecular imaging · 2025Article
- Advances and challenges in measuring hepatic glucose uptake with FDG PET: implications for diabetes research.Diabetologia · 2024Review
- Hepatic Positron Emission Tomography: Applications in Metabolism, Haemodynamics and Cancer.Metabolites · 2022Review
- Quantification of Liver Fat Content after Radiofrequency Ablation for Liver Cancer: Correlation with Hepatic Perfusion Disorders.Diagnostics (Basel, Switzerland) · 2021Article
- The Impact of Modern Chemotherapy and Chemotherapy-Associated Liver Injuries (CALI) on Liver Function: Value of 99mTc-Labelled-Mebrofenin SPECT-Hepatobiliary Scintigraphy.Annals of surgical oncology · 2021Article
- Dynamic PET of human liver inflammation: impact of kinetic modeling with optimization-derived dual-blood input function.Physics in medicine and biology · 2018Article
- Intrahepatic vascular changes in non-alcoholic fatty liver disease: Potential role of insulin-resistance and endothelial dysfunction.World journal of gastroenterology · 2017Review
- Non-alcoholic fatty liver disease, to struggle with the strangle: Oxygen availability in fatty livers.Redox biology · 2017Review
- The effect of water suppression on the hepatic lipid quantification, as assessed by the LCModel, in a preclinical and clinical scenario.Magma (New York, N.Y.) · 2016Article
- Metabolic syndrome and the hepatorenal reflex.Surgical neurology international · 2016Review
- Metabolic syndrome and the hepatorenal reflex.Surgical neurology international · 2016Review
- Serial measurement of hepatic lipids during chemotherapy in patients with colorectal cancer: a 1 H MRS study.NMR in biomedicine · 2013Article
- Cardioprotective properties of omentin-1 in type 2 diabetes: evidence from clinical and in vitro studies.PloS one · 2013Article
- Cross-sectional investigation of correlation between hepatic steatosis and IVIM perfusion on MR imaging.Magnetic resonance imaging · 2012Article
- Reduction in Tcf7l2 expression decreases diabetic susceptibility in mice.International journal of biological sciences · 2012Article
- Mitochondrial diabetes is associated with insulin resistance in subcutaneous adipose tissue but not with increased liver fat content.Journal of inherited metabolic disease · 2011Article
Corrections and comments
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveHepatic steatosis is common in type 2 diabetes. It is causally linked to the features of the metabolic syndrome, liver cirrhosis, and cardiovascular disease. Experimental data have indicated that increased liver fat may impair hepatic perfusion and metabolism. The aim of the current study was to assess hepatic parenchymal perfusion, together with glucose and fatty acid metabolism, in relation to hepatic triglyceride content. RESEARCH DESIGN AND
methodsFifty-nine men with well controlled type 2 diabetes and 18 age-matched healthy normoglycemic men were studied using positron emission tomography to assess hepatic tissue perfusion, insulin-stimulated glucose, and fasting fatty acid metabolism, respectively, in relation to hepatic triglyceride content, quantified by proton magnetic resonance spectroscopy. Patients were divided into two groups with hepatic triglyceride content below (type 2 diabetes-low) or above (type 2 diabetes-high) the median of 8.6%.
resultsType 2 diabetes-high patients had the highest BMI and A1C and lowest whole-body insulin sensitivity (ANOVA, all P < 0.001). Compared with control subjects and type 2 diabetes-low patients, type 2 diabetes-high patients had the lowest hepatic parenchymal perfusion (P = 0.004) and insulin-stimulated hepatic glucose uptake (P = 0.013). The observed decrease in hepatic fatty acid influx rate constant, however, only reached borderline significance (P = 0.088). In type 2 diabetic patients, hepatic parenchymal perfusion (r = -0.360, P = 0.007) and hepatic fatty acid influx rate constant (r = -0.407, P = 0.007) correlated inversely with hepatic triglyceride content. In a pooled analysis, hepatic fat correlated with hepatic glucose uptake (r = -0.329, P = 0.004).
conclusionsIn conclusion, type 2 diabetic patients with increased hepatic triglyceride content showed decreased hepatic parenchymal perfusion and hepatic insulin mediated glucose uptake, suggesting a potential modulating effect of hepatic fat on hepatic physiology.
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