Evidence map›Paper›PMID 20693247›Full record

Trial reportThe European respiratory journal2011

The minimal important difference of exercise tests in severe COPD.

M A Puhan, D Chandra, Z Mosenifar, A Ries, B Make, N N Hansel, R A Wise, F Sciurba, National Emphysema Treatment Trial (NETT) Research Group

2 registry-linked trialsOpen access · bronzeAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The European respiratory journal, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 154 papers, 28 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
154citing papers in PubMed, 28 pooled it
14.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02982876 nacompletednot on this mapstarted 2016, after this paper: background citation

Airway Stents for Excessive Dynamic Airway Collapse: A Randomized Controlled Trial

TypeinterventionalSponsorBeth Israel Deaconess Medical CenterRan2016 to 2024Enrolled50ConditionsTracheobronchomalacia, Excessive Dynamic Airway CollapseArmsDynamic Flexible Bronchoscopy, Rigid Bronchoscopy, Stent placement
NCT04217603 narecruitingnot on this mapstarted 2023, after this paper: background citation

Effect of Continuous Positive Airway Pressure (CPAP) on 6-Minute Walk Test Outcomes in Patients With Excessive Central Airway Collapse (ECAC)

TypeinterventionalSponsorBeth Israel Deaconess Medical CenterRan2023 to 2026Enrolled32ConditionsTracheobronchomalacia, Excessive Dynamic Airway CollapseArmsContinuous positive airway pressure (CPAP) device, Sham-continuous positive airway pressure (CPAP) device
3 · Its place in the literature

Who cites it

154 citing papers in PubMed, 28 syntheses or guidelines pooled it, 395 citations in OpenAlex.

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  9. Chronic non-invasive ventilation for chronic obstructive pulmonary disease.The Cochrane database of systematic reviews · 2021
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  11. Pulmonary rehabilitation for interstitial lung disease.The Cochrane database of systematic reviews · 2021
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94 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 3 countries.

M A PuhanDept of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA. mpuhan@jhsph.edu
D Chandra
Z Mosenifar
A Ries
B Make
N N Hansel
R A Wise
F Sciurba
National Emphysema Treatment Trial (NETT) Research Group
Johns Hopkins University · USUniversity of Pittsburgh · USCedars-Sinai Medical Center · USMcMaster University · CAUniversity of California System · US

Funding

Impact of CPAP on Functional Outcomes in Milder OSAR01HL076101 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI WEAVER, TERRI ELIZABETH · 2003 to 2006
$2.6M
Modeling of Lung HIV Cytokine/Chemokine NetworksR01HL076114 · NHLBI · BOSTON MEDICAL CENTER · PI SKOLNIK, PAUL R · 2003 to 2006
$1.8M
Training Program in Academic Pulmonary MedicineT32HL076118 · NHLBI · EMORY UNIVERSITY · PI HART, C MICHAEL · 2004 to 2013
$1.7M
Neurotrophins and Development of Baroreceptor Pathways.R01HL076113 · NHLBI · OREGON HEALTH & SCIENCE UNIVERSITY · PI BALKOWIEC, AGNIESZKA Z · 2005 to 2009
$1.5M
CLINICAL COORDINATING CENTER FOR LVRS-N01HR76119-268076119-268076119N01HR076119 · HR · JOHNS HOPKINS UNIVERSITY · PI PIANTADOSI, STEVEN · 1997 to 2006
$871k
Cardiovascular Development and Disease in the YoungT32HL076116 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI ROSEN, MICHAEL R. · 2004 to 2008
$577k
LUNG VOLUME REDUCTION SURGERY--CLINICAL CENTERN01HR076118 · HR · UNIVERSITY OF WASHINGTON · PI ALBERT, RICHARD K · 1997 to 2000
$225k
LUNG VOLUME REDUCTION SURGERY--CLINICAL CENTERN01HR076113 · HR · UNIVERSITY OF PENNSYLVANIA · PI KAISER, LARRY · 1997 to 2000
$208k
CLNICAL CENTER FOR LVRSN01HR076104 · HR · CEDARS-SINAI MEDICAL CENTER · PI MCKENNA, RICHARD · 1997 to 2000
$153k
CLNICAL CENTER FOR THE LVRSN01HR076102 · HR · BRIGHAM AND WOMEN'S HOSPITAL · PI REILLY, JOHN J · 1997 to 2000
$150k
CLINICAL CENTER FOR LVRSN01HR076114 · HR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KEENAN, ROBERT J · 1997 to 2000
$147k
LUNG VOLUME REDUCTION SURGERY--CLINICAL CENTERN01HR076110 · HR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI FERNANDO, MARTINEZ J · 1997 to 2000
$146k
NHLBI NIH HHS N01 HR076101NHLBI NIH HHS N01 HR076102NHLBI NIH HHS N01 HR076103NHLBI NIH HHS N01 HR076104NHLBI NIH HHS N01 HR076105NHLBI NIH HHS N01 HR076106NHLBI NIH HHS N01 HR076107NHLBI NIH HHS N01 HR076108NHLBI NIH HHS N01 HR076109NHLBI NIH HHS N01 HR076110NHLBI NIH HHS N01 HR076111NHLBI NIH HHS N01 HR076112NHLBI NIH HHS N01 HR076113NHLBI NIH HHS N01 HR076114NHLBI NIH HHS N01 HR076115NHLBI NIH HHS N01 HR076116NHLBI NIH HHS N01 HR076118NHLBI NIH HHS N01 HR076119NHLBI NIH HHS N01HR76115
6 · The paper itself

Abstract

Our aim was to determine the minimal important difference (MID) for 6-min walk distance (6MWD) and maximal cycle exercise capacity (MCEC) in patients with severe chronic obstructive pulmonary disease (COPD). 1,218 patients enrolled in the National Emphysema Treatment Trial completed exercise tests before and after 4-6 weeks of pre-trial rehabilitation, and 6 months after randomisation to surgery or medical care. The St George's Respiratory Questionnaire (domain and total scores) and University of California San Diego Shortness of Breath Questionnaire (total score) served as anchors for anchor-based MID estimates. In order to calculate distribution-based estimates, we used the standard error of measurement, Cohen's effect size and the empirical rule effect size. Anchor-based estimates for the 6MWD were 18.9 m (95% CI 18.1-20.1 m), 24.2 m (95% CI 23.4-25.4 m), 24.6 m (95% CI 23.4-25.7 m) and 26.4 m (95% CI 25.4-27.4 m), which were similar to distribution-based MID estimates of 25.7, 26.8 and 30.6 m. For MCEC, anchor-based estimates for the MID were 2.2 W (95% CI 2.0-2.4 W), 3.2 W (95% CI 3.0-3.4 W), 3.2 W (95% CI 3.0-3.4 W) and 3.3 W (95% CI 3.0-3.5 W), while distribution-based estimates were 5.3 and 5.5 W. We suggest a MID of 26 ± 2 m for 6MWD and 4 ± 1 W for MCEC for patients with severe COPD.

Indexed as

AgedCohort StudiesExercise TestExercise ToleranceFemaleForced Expiratory VolumeHumansMaleMiddle AgedModels, StatisticalOxygenPulmonary Disease, Chronic ObstructiveResearch DesignSurveys and QuestionnairesWalkingOxygen

Identifiers

PMID20693247
PMCPMC5516638
OpenAlexW2100799766

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.