Evidence map›Paper›PMID 20692762›Full record

ReviewCancer letters2011

Helicobacter pylori in the pathogenesis of gastric cancer and gastric lymphoma.

Sung Soo Kim, Victoria E Ruiz, Jaqueline D Carroll, Steven F Moss

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cancer letters, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 90 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
90citing papers in PubMed, 4 pooled it
10.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

90 citing papers in PubMed, 4 syntheses or guidelines pooled it, 211 citations in OpenAlex.

  1. TLR2 variants andUpsala journal of medical sciences · 2025
    Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Review
  6. Frontiers in gastroenterology (Lausanne, Switzerland) · 2026
    Review
  7. Article
  8. Article
  9. Review
  10. Article
  11. NO: a key player in microbiome dynamics and cancer pathogenesis.Frontiers in cellular and infection microbiology · 2025
    Review
  12. The immunoregulatory role of helper T cells inFrontiers in immunology · 2025
    Review
  13. Article
  14. Article
  15. Review
  16. Article
  17. Review
  18. Periodontitis and progression of gastrointestinal cancer: current knowledge and future perspective.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2023
    Review
  19. Global prevalence ofHealth science reports · 2023
    Article
  20. Article

30 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

Sung Soo KimDepartment of Internal Medicine, Uijongbu St. Mary Hospital, Catholic University of Korea, Seoul, Republic of Korea.
Victoria E Ruiz
Jaqueline D Carroll
Steven F Moss
Brown University · USCatholic University of Korea · KRRhode Island Hospital · US

Funding

p27 & apoptosis resistance in gastric cancerR01CA111533 · NCI · RHODE ISLAND HOSPITAL · PI MOSS, STEVEN F · 2006 to 2010
$1.2M
GASTRIC CANCER INDUCED BY H PYLORI IN P27 DEFICIENT MICER21CA125126 · NCI · RHODE ISLAND HOSPITAL · PI MOSS, STEVEN F · 2008 to 2009
$335k
H. Pylori infection and manipulation of the host inflammatory responseF31AI082948 · NIAID · BROWN UNIVERSITY · PI RUIZ, VICTORIA ELIZABETH · 2009 to 2010
$79k
NCI NIH HHS R01 CA111533NCI NIH HHS R01CA111533-01NCI NIH HHS R21 CA125126NCI NIH HHS R21CA125126-01NIAID NIH HHS 1F31AI082948-01NIAID NIH HHS F31 AI082948
6 · The paper itself

Abstract

Chronic gastric infection by the gram-negative bacterium Helicobacter pylori is strongly associated with the development of distal gastric carcinoma and gastric mucosal lymphoma in humans. Eradication of H. pylori with combination antibiotic therapy cures most cases of gastric lymphoma and slows progression to gastric adenocarcinoma. H. pylori promotes gastric neoplasia, principally via the induction of an intense gastric inflammatory response that lasts over decades. This persistent inflammatory state produces chronic oxidative stress and adaptive changes in gastric epithelial and immune cell pathobiology that in a minority of infected subjects eventually proceeds to frank neoplastic transformation.

Indexed as

AdenocarcinomaAntigens, BacterialBacterial ProteinsDisease ProgressionDNA DamageGenome, BacterialGenomicsHelicobacter pyloriHumansInflammationLymphomaOxidative StressStomach NeoplasmsAntigens, BacterialBacterial Proteins

Identifiers

PMID20692762
PMCPMC2980557
OpenAlexW2110507552

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.