ArticleJournal of the American Academy of Dermatology2010
A pilot study of emollient therapy for the primary prevention of atopic dermatitis.
Article in Journal of the American Academy of Dermatology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
39 citing papers in PubMed, 2 syntheses or guidelines pooled it, 180 citations in OpenAlex.
- Emollients and moisturisers for eczema.The Cochrane database of systematic reviews · 2017Pooled it
- How should an incident case of atopic dermatitis be defined? A systematic review of primary prevention studies.The Journal of allergy and clinical immunology · 2012Pooled it
- Emollient application from birth to prevent eczema in high-risk children: the BEEP RCT.Health technology assessment (Winchester, England) · 2024Trial
- Moisturisers from birth in at-risk infants of atopic dermatitis - a pragmatic randomised controlled trial.The Australasian journal of dermatology · 2021Trial
- Effect of filaggrin loss-of-function mutations on atopic dermatitis in young age: a longitudinal birth cohort study.Journal of human genetics · 2019Trial
- Emollient use alters skin barrier and microbes in infants at risk for developing atopic dermatitis.PloS one · 2018Trial
- Emollient enhancement of the skin barrier from birth offers effective atopic dermatitis prevention.The Journal of allergy and clinical immunology · 2014Trial
- Atopic dermatitis.Nature reviews. Disease primers · 2026Review
- Maternal Nutritional Status and Development of Atopic Dermatitis in Their Offspring.Clinical reviews in allergy & immunology · 2021Review
- Management of Atopic Dermatitis in Children Younger Than Two Years of Age by Community Pediatricians: A Survey and Chart Review.The Journal of pediatrics · 2020Article
- Article
- Halting the March: Primary Prevention of Atopic Dermatitis and Food Allergies.The journal of allergy and clinical immunology. In practice · 2020Article
- Atopic dermatitis. Interdisciplinary diagnostic and therapeutic recommendations of the Polish Dermatological Society, Polish Society of Allergology, Polish Pediatric Society and Polish Society of Family Medicine. Part I. Prophylaxis, topical treatment and phototherapy.Postepy dermatologii i alergologii · 2020Article
- Suppression of DNCB-Induced Atopic Skin Lesions in Mice byNutrients · 2020Article
- A Systematic Scoping Literature Review of Publications Supporting Treatment Guidelines for Pediatric Atopic Dermatitis in Contrast to Clinical Practice Patterns.Dermatology and therapy · 2018Article
- Noninvasive monitoring of plant-based formulations on skin barrier properties in infants with dry skin and risk for atopic dermatitis.International journal of women's dermatology · 2018Article
- Significance of Skin Barrier Dysfunction in Atopic Dermatitis.Allergy, asthma & immunology research · 2018Review
- A Real-Life Based Evaluation of the Effectiveness of Antibacterial Fabrics in Treating Atopic Dermatitis.Dermatology research and practice · 2018Article
- Prevention of allergies in childhood - where are we now?Allergologie select · 2017Review
- Recommendations from a European Roundtable Meeting on Best Practice Healthy Infant Skin Care.Pediatric dermatology · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
backgroundPrevention strategies in atopic dermatitis (AD) using allergen avoidance have not been consistently effective. New research reveals the importance of the skin barrier in the development of AD and possibly food allergy and asthma. Correcting skin barrier defects from birth may prevent AD onset or moderate disease severity.
objectiveWe sought to determine the feasibility of skin barrier protection as a novel AD prevention strategy.
methodsWe enrolled 22 neonates at high risk for developing AD in a feasibility pilot study using emollient therapy from birth.
resultsNo intervention-related adverse events occurred in our cohort followed up for a mean time of 547 days. Of the 20 subjects who remained in the study, 3 (15.0%) developed AD, suggesting a protective effect when compared with historical controls. Skin barrier measurements remained within ranges seen in normal-appearing skin. LIMITATIONS: No conclusions regarding efficacy can be made without a control group.
conclusionsSkin barrier repair from birth represents a novel and feasible approach to AD prevention. Further studies are warranted to determine the efficacy of this approach.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.