Evidence map›Paper›PMID 20692608›Full record

ArticleCurrent biology : CB2010

Signal transduction: RABGEF1 fingers RAS for ubiquitination.

John Colicelli

Open access · bronzeAbstract readComment
In one paragraph

Article in Current biology : CB, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 17 citations in OpenAlex.

  1. Comprehensive characterization of the RNA editing landscape in the human aging brains with Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

1 author at 1 institution.

John ColicelliDepartment of Biological Chemistry, Molecular Biology Institute and Jonsson Comprehensive Cancer Center, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA. colicelli@mednet.ucla.edu
UCLA Jonsson Comprehensive Cancer Center

Funding

A Novel Screen for Compounds that Outflank BCR-ABL Drug-ResistanceR01CA136699 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI COLICELLI, JOHN J. · 2009 to 2011
$937k
NCI NIH HHS R01 CA136699
6 · The paper itself

Abstract

RAS proteins conduct signaling from surface receptors to cytoplasmic effectors, and RAS gain-of-function mutations are pervasive in cancer. A new mechanism for RAS signal attenuation with implications for receptor trafficking has been uncovered.

Indexed as

AnimalsEndosomesGuanine Nucleotide Exchange FactorsHumansras ProteinsSignal TransductionUbiquitinationGuanine Nucleotide Exchange FactorsRABGEF1 protein, humanras Proteins

Identifiers

PMID20692608
PMCPMC2950067
OpenAlexW2060212847

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.