ArticleMolecular and cellular neurosciences2010
Uncx regulates proliferation of neural progenitor cells and neuronal survival in the olfactory epithelium.
Article in Molecular and cellular neurosciences, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 36 citations in OpenAlex.
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- Anosmin-1-Like Effect of UMODL1/Olfactorin on the Chemomigration of Mouse GnRH Neurons and Zebrafish Olfactory Axons Development.Frontiers in cell and developmental biology · 2022Article
- Human APOE ɛ3 and APOE ɛ4 Alleles Have Differential Effects on Mouse Olfactory Epithelium.Journal of Alzheimer's disease : JAD · 2022Article
- Morphological Characterization ofMolecules and cells · 2021Article
- Single-cell analysis supports a luminal-neuroendocrine transdifferentiation in human prostate cancer.Communications biology · 2020Article
- Maturation of the Olfactory Sensory Neuron and Its Cilia.Chemical senses · 2020Review
- Characterization of paralogousGene: X · 2019Article
- Single-cell transcriptomics reveals gene expression dynamics of human fetal kidney development.PLoS biology · 2019Article
- Transcriptional and Epigenetic Control of Mammalian Olfactory Epithelium Development.Molecular neurobiology · 2018Review
- Epigenetically induced ectopic expression of UNCX impairs the proliferation and differentiation of myeloid cells.Haematologica · 2017Article
- The human olfactory transcriptome.BMC genomics · 2016Article
- Translational potential of olfactory mucosa for the study of neuropsychiatric illness.Translational psychiatry · 2015Review
- Article
- Molecular events in the cell types of the olfactory epithelium during adult neurogenesis.Molecular brain · 2013Article
- The transcription factor Uncx4.1 acts in a short window of midbrain dopaminergic neuron differentiation.Neural development · 2012Article
- Overexpression of Uromodulin-like1 accelerates follicle depletion and subsequent ovarian degeneration.Cell death & disease · 2012Article
- Genomics of mature and immature olfactory sensory neurons.The Journal of comparative neurology · 2012Article
- Genes expressed in Atoh1 neuronal lineages arising from the r1/isthmus rhombic lip.Gene expression patterns : GEPArticle
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Uncx (Phd1, Chx4) is a paired homeobox transcription factor gene. It and its probable functional partners, Tle co-repressors, were expressed by neurally-fated basal progenitor cells and olfactory sensory neurons of the olfactory epithelium. Uncx expression was rare in olfactory epithelia of Ascl1(-/-) mice, but common in Neurog1(-/-) mice. In Uncx(-/-) mice olfactory progenitor cell proliferation, progenitor cell number, olfactory sensory neuron survival, and Umodl1 and Kcnc4 mRNAs were reduced. Evidence of sensory neuron activity and functional connections to the olfactory bulb argue that decreased neuronal survival was not due to loss of trophic support or activity-dependent mechanisms. These data suggest that UNCX acts downstream of neural determination factors to broadly control transcriptional mechanisms used by neural progenitor cells to specify neural phenotypes.
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