ArticleNeuroscience letters2010
State-dependent sculpting of olfactory sensory neurons is attributed to sensory enrichment, odor deprivation, and aging.
Article in Neuroscience letters, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 46 citations in OpenAlex.
- Lack of Structural Change in Olfactory Circuitry Following Fecal Microbiome Transplant From Donors Subjected to Diet-induced Obesity.Journal of neurochemistry · 2026Article
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- New Neurons in the Postnatal Olfactory System: Functions in the Healthy and Regenerating Brain.Brain sciences · 2025Review
- Sex Differences in the Anxiolytic Properties of Common Cannabis Terpenes, Linalool and β-Myrcene, in Mice.NeuroSci · 2024Article
- The Role of the Stimulus in Olfactory Plasticity.Brain sciences · 2023Review
- Article
- The effect of odor enrichment on olfactory acuity: Olfactometric testing in mice using two mirror-molecular pairs.PloS one · 2020Article
- Gene expression profiling of the olfactory tissues of sex-separated and sex-combined female and male mice.Scientific data · 2018Article
- Sex separation induces differences in the olfactory sensory receptor repertoires of male and female mice.Nature communications · 2018Article
- Bilateral Olfactory Mucosa Damage Induces the Disappearance of Olfactory Glomerulus and Reduces the Expression of Extrasynaptic α5GABANeurotoxicity research · 2018Article
- Activity-Dependent Gene Expression in the Mammalian Olfactory Epithelium.Chemical senses · 2017Review
- Variation in olfactory neuron repertoires is genetically controlled and environmentally modulated.eLife · 2017Article
- Early Odorant Exposure Increases the Number of Mitral and Tufted Cells Associated with a Single Glomerulus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Changes in Olfactory Sensory Neuron Physiology and Olfactory Perceptual Learning After Odorant Exposure in Adult Mice.Chemical senses · 2016Article
- Injury in aged animals robustly activates quiescent olfactory neural stem cells.Frontiers in neuroscience · 2015Article
- Hyperlipidemic diet causes loss of olfactory sensory neurons, reduces olfactory discrimination, and disrupts odor-reversal learning.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Postnatal odorant exposure induces peripheral olfactory plasticity at the cellular level.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Aging in the olfactory system.Trends in neurosciences · 2014Review
- A lifetime of neurogenesis in the olfactory system.Frontiers in neuroscience · 2014Review
- Odor enrichment sculpts the abundance of olfactory bulb mitral cells.Neuroscience letters · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Gene-targeted deletion of the predominant Shaker potassium channel, Kv1.3, in the mitral cells of the olfactory bulb, decreases the number of presynaptic, odorant receptor (OR)-identified olfactory sensory neurons (OSNs) in the main olfactory epithelium (MOE) and alters the nature of their postsynaptic connections to mitral cell targets. The current study examined whether OSN density was state-dependent by examining the impact of (1) odor enrichment, (2) sensory deprivation, and (3) aging upon the number of P2- or M72-expressing neurons. Histological approaches were used to quantify the number of OSNs across entire epithelia for wildtype (WT) vs. Kv1.3-null (KO) mice bred onto an ORtauLacZ reporter background. Following either odor enrichment or early unilateral naris-occlusion, the number of M72-expressing OSNs was significantly decreased in WT mice, but was unchanged in KO animals. Following naris-occlusion, the number of P2-expressing OSNs was decreased regardless of genotype. Animals that were reared to 2 years of age demonstrated loss of both P2- and M72-expressing OSNs in WT mice and a concomitant loss of only M72-expressing neurons in KO mice. These findings suggest that voltage-gated activity of the mitral cells is important for OSN plasticity, and can prevent neuronal loss via sensory- and OR-dependent mechanisms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.