ArticleImmunity2010
Follicular B cell trafficking within the spleen actively restricts humoral immune responses.
Article in Immunity, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
40 citing papers in PubMed.
- Epigenetic signatures mark early peripheral human B lineage bifurcation and differential transcriptional profiles in mature populations.Nature communications · 2026Article
- Involvement of SWAP-70 in proteolipid protein-induced experimental autoimmune encephalomyelitis.Turkish journal of medical sciences · 2026Article
- Article
- Immature B cell homing shapes human lymphoid tissue structure and function.The Journal of experimental medicine · 2024Article
- Eomesodermin spatiotemporally orchestrates the early and late stages of NK cell development by targeting KLF2 and T-bet, respectively.Cellular & molecular immunology · 2024Article
- The genomic and molecular landscape of splenic marginal zone lymphoma, biological and clinical implications.Exploration of targeted anti-tumor therapy · 2024Review
- Interactions between B cells and T follicular regulatory cells enhance susceptibility to Brucella infection independent of the anti-Brucella humoral response.PLoS pathogens · 2023Article
- Regulation of the MyD88 gene in chicken spleen inflammation induced by stress.Journal of animal science · 2023Article
- Integrin β1 regulates marginal zone B cell differentiation and PI3K signaling.The Journal of experimental medicine · 2023Article
- Krüppel-like factor 2: a central regulator of B cell differentiation and plasma cell homing.Frontiers in immunology · 2023Review
- Krüppel-like factor 2 controls IgA plasma cell compartmentalization and IgA responses.Mucosal immunology · 2022Article
- Review
- Heterozygous premature termination in zinc-finger domain of Krüppel-like factor 2 gene associates with dysregulated immunity.Frontiers in immunology · 2022Article
- Characterization of spleen and lymph node cell typesFrontiers in molecular neuroscience · 2022Article
- Krüppel-like Factor 2 (KLF2) in Immune Cell Migration.Vaccines · 2021Review
- The Zinc Finger Protein Zbtb18 Represses Expression of Class I Phosphatidylinositol 3-Kinase Subunits and Inhibits Plasma Cell Differentiation.Journal of immunology (Baltimore, Md. : 1950) · 2021Article
- Notch2-mediated plasticity between marginal zone and follicular B cells.Nature communications · 2021Article
- EZH2 Represses the B Cell Transcriptional Program and Regulates Antibody-Secreting Cell Metabolism and Antibody Production.Journal of immunology (Baltimore, Md. : 1950) · 2018Article
- KLF2 in Regulation of NF-κB-Mediated Immune Cell Function and Inflammation.International journal of molecular sciences · 2017Review
- Maintenance of the marginal-zone B cell compartment specifically requires the RNA-binding protein ZFP36L1.Nature immunology · 2017Article
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Authors and funding
9 authors.
Funding
Abstract
Follicular (FO) and marginal zone (MZ) B cells are maintained in distinct locations within the spleen, but the genetic basis for this separation is still enigmatic. We now report that B cell sequestration requires lineage-specific regulation of migratory receptors by the transcription factor Klf2. Moreover, using gene-targeted mice we show that altered splenic B cell migration confers a significant in vivo gain-of-function phenotype to FO B cells, including the ability to quickly respond to MZ-associated antigens and pathogens in a T cell-dependent manner. This work demonstrates that in wild-type animals, naive FO B cells are actively removed from the MZ, thus restricting their capacity to respond to blood-borne pathogens.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.