ArticleBiological psychiatry2010
Genetic associations of brain structural networks in schizophrenia: a preliminary study.
Article in Biological psychiatry, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
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Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 56 citations in OpenAlex.
- Japanese Cohort Study and Meta-Analysis Demonstrate Significant Association Between Serotonin Transporter-Linked Polymorphic Region and Schizophrenia.Neuropsychopharmacology reports · 2026Pooled it
- Network localization of genetic risk for schizophrenia and bipolar disorder.Psychological medicine · 2025Article
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- The Neurobiological Underpinnings of Obsessive-Compulsive Symptoms in Psychosis, Translational Issues for Treatment-Resistant Schizophrenia.Biomolecules · 2023Review
- Assessment of DDAH1 and DDAH2 Contributions to Psychiatric Disorders via In Silico Methods.International journal of molecular sciences · 2022Article
- Elevated endogenous GDNF induces altered dopamine signalling in mice and correlates with clinical severity in schizophrenia.Molecular psychiatry · 2022Article
- Reward Deficiency Syndrome (RDS) Surprisingly Is Evolutionary and Found Everywhere: Is It "Blowin' in the Wind"?Journal of personalized medicine · 2022Article
- Time to Recover From Daily Caffeine Intake.Frontiers in nutrition · 2021Article
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- Association between theNeuropsychiatric disease and treatment · 2019Article
- A framework for linking resting-state chronnectome/genome features in schizophrenia: A pilot study.NeuroImage · 2019Article
- Multimodal fusion of brain imaging data: A key to finding the missing link(s) in complex mental illness.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2016Article
- The association of ADORA2A and ADORA2B polymorphisms with the risk and severity of chronic heart failure: a case-control study of a northern Chinese population.International journal of molecular sciences · 2015Article
- Hepatocyte nuclear factor 4 alpha is a key factor related to depression and physiological homeostasis in the mouse brain.PloS one · 2015Article
- Genetic underpinnings of white matter 'connectivity': heritability, risk, and heterogeneity in schizophrenia.Schizophrenia research · 2015Review
- Function-structure associations of the brain: evidence from multimodal connectivity and covariance studies.NeuroImage · 2014Review
- Imaging proteomics for diagnosis, monitoring and prediction of Alzheimer's disease.NeuroImage · 2014Article
- A review of multivariate analyses in imaging genetics.Frontiers in neuroinformatics · 2014Review
- Genetic influences of resting state fMRI activity in language-related brain regions in healthy controls and schizophrenia patients: a pilot study.Brain imaging and behavior · 2013Article
Corrections and comments
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Authors and funding
10 authors at 8 institutions in 1 country.
Funding
Abstract
backgroundSchizophrenia is a complex genetic disorder, with multiple putative risk genes and many reports of reduced cortical gray matter. Identifying the genetic loci contributing to these structural alterations in schizophrenia (and likely also to normal structural gray matter patterns) could aid understanding of schizophrenia's pathophysiology. We used structural parameters as potential intermediate illness markers to investigate genomic factors derived from single nucleotide polymorphism (SNP) arrays.
methodWe used research quality structural magnetic resonance imaging (sMRI) scans from European American subjects including 33 healthy control subjects and 18 schizophrenia patients. All subjects were genotyped for 367 SNPs. Linked sMRI and genetic (SNP) components were extracted to reveal relationships between brain structure and SNPs, using parallel independent component analysis, a novel multivariate approach that operates effectively in small sample sizes.
resultsWe identified an sMRI component that significantly correlated with a genetic component (r = -.536, p < .00005); components also distinguished groups. In the sMRI component, schizophrenia gray matter deficits were in brain regions consistently implicated in previous reports, including frontal and temporal lobes and thalamus (p < .01). These deficits were related to SNPs from 16 genes, several previously associated with schizophrenia risk and/or involved in normal central nervous system development, including AKT, PI3K, SLC6A4, DRD2, CHRM2, and ADORA2A.
conclusionsDespite the small sample size, this novel analysis method identified an sMRI component including brain areas previously reported to be abnormal in schizophrenia and an associated genetic component containing several putative schizophrenia risk genes. Thus, we identified multiple genes potentially underlying specific structural brain abnormalities in schizophrenia.
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