Evidence map›Paper›PMID 20691420›Full record

ArticleAmerican journal of ophthalmology2010

Identification of new pathogens in the intraocular fluid of patients with uveitis.

Jolanda D F de Groot-Mijnes, Lenneke de Visser, Stephanie Zuurveen, Roaldy A Martinus, René Völker, Ninette H ten Dam-van Loon, Joke H de Boer, Gina Postma, Raoul J de Groot, Anton M van Loon and 1 more

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In one paragraph

Article in American journal of ophthalmology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
4.6field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 80 citations in OpenAlex.

  1. Article
  2. Comparative analysis of iridian anterior segment OCT and microbiological features in Fuchs Uveitis Syndrome and Posner-Schlossman Syndrome.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2025
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  17. The particulars on parechovirus.The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2014
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  19. Review
  20. Searching for viral antibodies and genome in intraocular fluids of patients with Fuchs uveitis and non-infectious uveitis.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2013
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Jolanda D F de Groot-MijnesDepartment of Virology, University Medical Center Utrecht, The Netherlands. J.D.FdeGroot@umcutrecht.nl
Lenneke de Visser
Stephanie Zuurveen
Roaldy A Martinus
René Völker
Ninette H ten Dam-van Loon
Joke H de Boer
Gina Postma
Raoul J de Groot
Anton M van Loon
Aniki Rothova
University Medical Center Utrecht · NLUtrecht University · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo determine infectious causes in patients with uveitis of unknown origin by intraocular fluids analysis.

designCase-control study.

methodsOcular fluids from 139 patients suspected of infectious uveitis, but negative for herpes simplex virus, varicella-zoster virus, cytomegalovirus, and Toxoplasma gondii by polymerase chain reaction and/or antibody analysis in intraocular fluids, were assessed for the presence of 18 viruses and 3 bacteria by real-time polymerase chain reaction (PCR). The ocular fluids from 48 patients with uveitis of known etiology or with cataract were included as controls.

resultsPositive PCR results were found for Epstein-Barr virus, for rubella virus, and for human herpesvirus 6 each in 1 patient and for human parechovirus in 4 patients. Of the human parechovirus-positive patients, 1 was immunocompromised and had panuveitis. The other 3 patients were immunocompetent and had anterior uveitis, all with corneal involvement.

conclusionsHuman parechovirus might be associated with infectious (kerato)uveitis.

Indexed as

AdultAgedAntibodies, ViralAqueous HumorCase-Control StudiesDNA PrimersDNA, ViralEnzyme-Linked Immunosorbent AssayEpstein-Barr Virus InfectionsEye Infections, ViralFemaleFluorescent Antibody Technique, IndirectHerpesvirus 4, HumanHerpesvirus 6, HumanHumansMaleAntibodies, ViralDNA PrimersDNA, Viral

Identifiers

PMID20691420
PMCPMC7093850
OpenAlexW2068309909

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.