ReviewPharmacological research2010
Tea catechins as inhibitors of receptor tyrosine kinases: mechanistic insights and human relevance.
Review in Pharmacological research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 59 citations in OpenAlex.
- The interplay of exercise and green tea: a new road in cancer therapy.Cancer cell international · 2025Review
- Phenolic Composition ofPharmaceuticals (Basel, Switzerland) · 2024Article
- Anticancer Therapeutic Effects of Green Tea Catechins (GTCs) When Integrated with Antioxidant Natural Components.Molecules (Basel, Switzerland) · 2023Review
- Computational insights into the stereo-selectivity of catechins for the inhibition of the cancer therapeutic target EGFR kinase.Frontiers in pharmacology · 2023Article
- Modern aspects of the use of natural polyphenols in tumor prevention and therapy.Frontiers in cell and developmental biology · 2022Review
- Hemp Seeds in Post-Arthroplasty Rehabilitation: A Pilot Clinical Study and an In Vitro Investigation.Nutrients · 2021Article
- PARP-1-Associated Pathological Processes: Inhibition by Natural Polyphenols.International journal of molecular sciences · 2021Review
- Flavonoids: structure-function and mechanisms of action and opportunities for drug development.Toxicological research · 2021Review
- Comparative study of young shoots and the mature red headed cabbage as antioxidant food resources with antiproliferative effect on prostate cancer cells.RSC advances · 2020Article
- (-)-Epigallocatechin-3-Gallate (EGCG) Enhances Osteogenic Differentiation of Human Bone Marrow Mesenchymal Stem Cells.Molecules (Basel, Switzerland) · 2018Article
- Possible Mechanisms of Green Tea and Its Constituents against Cancer.Molecules (Basel, Switzerland) · 2018Review
- Green Tea Catechins for Prostate Cancer Prevention: Present Achievements and Future Challenges.Antioxidants (Basel, Switzerland) · 2017Review
- Molecular signaling mechanisms behind polyphenol-induced bone anabolism.Phytochemistry reviews : proceedings of the Phytochemical Society of Europe · 2017Review
- Cancer Preventive Activities of Tea Catechins.Molecules (Basel, Switzerland) · 2016Review
- Comparison of anti-inflammatory mechanisms of mango (Mangifera Indica L.) and pomegranate (Punica Granatum L.) in a preclinical model of colitis.Molecular nutrition & food research · 2016Article
- Stability of Polyphenols Epigallocatechin Gallate and Pentagalloyl Glucose in a Simulated Digestive System.Food research international (Ottawa, Ont.) · 2012Article
- Inhibition of Eph receptor-ephrin ligand interaction by tea polyphenols.Pharmacological research · 2012Article
- MicroRNAs, diet, and cancer: new mechanistic insights on the epigenetic actions of phytochemicals.Molecular carcinogenesis · 2012Review
- Sinecatechins: Effects on HPV-Induced Enzymes Involved in Inflammatory Mediator Generation.The Journal of clinical and aesthetic dermatology · 2012Article
- Endothelins and their receptors in cancer: identification of therapeutic targets.Pharmacological research · 2011Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
Receptor tyrosine kinases (RTKs) play important roles in the control of fundamental cellular processes, influencing the balance between cell proliferation and death. RTKs have emerged as molecular targets for the treatment of various cancers. Green tea and its polyphenolic compounds, the catechins, exhibit chemopreventive and chemotherapeutic properties in many human cancer cell types, as well as in various carcinogenicity models in vivo. Epidemiological studies are somewhat less convincing, but some positive correlations have been observed. The tea catechins, including (-)-epigallocatechin-3-gallate (EGCG), have pleiotropic effects on cellular proteins and signaling pathways. This review focuses on the ability of the tea constituents to suppress RTK signaling, and summarizes the mechanisms by which EGCG and other catechins might exert their protective effects towards dysregulated RTKs in cancer cells. The findings are discussed in the context of ongoing clinical trials with RTK inhibitors, and the possibility for drug/nutrient interactions enhancing therapeutic efficacy.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.