ArticleBiological psychology2010
A genome-wide association study of Cloninger's temperament scales: implications for the evolutionary genetics of personality.
Article in Biological psychology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 6 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
42 citing papers in PubMed, 6 syntheses or guidelines pooled it.
- Meta-analysis of Genome-Wide Association Studies for Extraversion: Findings from the Genetics of Personality Consortium.Behavior genetics · 2016Pooled it
- GWA meta-analysis of personality in Korean cohorts.Journal of human genetics · 2015Pooled it
- Genetic and environmental continuity in personality development: a meta-analysis.Psychological bulletin · 2014Pooled it
- The molecular genetic architecture of self-employment.PloS one · 2013Pooled it
- A genome-wide meta-analysis of association studies of Cloninger's Temperament Scales.Translational psychiatry · 2012Pooled it
- Meta-analysis of genome-wide association studies identifies common variants in CTNNA2 associated with excitement-seeking.Translational psychiatry · 2011Pooled it
- The sinking platform test: a novel paradigm to measure persistence in animal models.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Article
- Temperament impact on eating disorder symptoms and habit formation: a novel model to inform treatment.Journal of eating disorders · 2024Review
- Increased burden of rare protein-truncating variants in constrained, brain-specific and synaptic genes in extremely impulsively violent males with antisocial personality disorder.Genes, brain, and behavior · 2024Article
- Review
- Understanding Anhedonia from a Genomic Perspective.Current topics in behavioral neurosciences · 2022Review
- Uncovering the complex genetics of human character.Molecular psychiatry · 2020Article
- Uncovering the complex genetics of human temperament.Molecular psychiatry · 2020Article
- Genetic control of temperament traits across species: association of autism spectrum disorder risk genes with cattle temperament.Genetics, selection, evolution : GSE · 2020Article
- Does inbreeding affect personality traits?Ecology and evolution · 2019Article
- Modeling human temperament and character on the basis of combined theoretical approaches.Annals of general psychiatry · 2019Article
- Unravelling the interaction between theBMJ open sport & exercise medicine · 2019Article
- Resting-state functional brain connectivity best predicts the personality dimension of openness to experience.Personality neuroscience · 2018Article
- Genetics of biologically based psychological differences.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2018Review
- What is the natural measurement unit of temperament: single traits or profiles?Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2018Review
Corrections and comments
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Authors and funding
14 authors.
Funding
Abstract
Variation in personality traits is 30-60% attributed to genetic influences. Attempts to unravel these genetic influences at the molecular level have, so far, been inconclusive. We performed the first genome-wide association study of Cloninger's temperament scales in a sample of 5117 individuals, in order to identify common genetic variants underlying variation in personality. Participants' scores on Harm Avoidance, Novelty Seeking, Reward Dependence, and Persistence were tested for association with 1,252,387 genetic markers. We also performed gene-based association tests and biological pathway analyses. No genetic variants that significantly contribute to personality variation were identified, while our sample provides over 90% power to detect variants that explain only 1% of the trait variance. This indicates that individual common genetic variants of this size or greater do not contribute to personality trait variation, which has important implications regarding the genetic architecture of personality and the evolutionary mechanisms by which heritable variation is maintained.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.