ArticleBrain research2010
Co-localization of TRHR1 and LepRb receptors on neurons in the hindbrain of the rat.
Article in Brain research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 33 citations in OpenAlex.
- Development of Insulin and Leptin Resistance in the Mouse Brainstem with Age.Molecular neurobiology · 2026Article
- Leptin and Associated Neural Pathways Underlying Obesity-Induced Hypertension.Comprehensive Physiology · 2025Review
- Rifaximin modulates TRH and TRH-like peptide expression throughout the brain and peripheral tissues of male rats.BMC neuroscience · 2022Article
- Leptin Receptor Signaling in Sim1-Expressing Neurons Regulates Body Temperature and Adaptive Thermogenesis.Endocrinology · 2019Article
- The melanocortin pathway and control of appetite-progress and therapeutic implications.The Journal of endocrinology · 2019Review
- Responsiveness of hypothalamo-pituitary-adrenal axis to leptin is impaired in diet-induced obese rats.Nutrition & diabetes · 2019Article
- Amylin-mediated control of glycemia, energy balance, and cognition.Physiology & behavior · 2016Review
- Facilitation of breathing by leptin effects in the central nervous system.The Journal of physiology · 2016Review
- The use of animal models to decipher physiological and neurobiological alterations of anorexia nervosa patients.Frontiers in endocrinology · 2015Review
- Impaired neural structure and function contributing to autonomic symptoms in congenital central hypoventilation syndrome.Frontiers in neuroscience · 2015Review
- Neural innervation of white adipose tissue and the control of lipolysis.Frontiers in neuroendocrinology · 2014Review
- Leptin receptor neurons in the dorsomedial hypothalamus are key regulators of energy expenditure and body weight, but not food intake.Molecular metabolism · 2014Article
- Leptin into the ventrolateral medulla facilitates chemorespiratory response in leptin-deficient (ob/ob) mice.Acta physiologica (Oxford, England) · 2014Article
- Affective brain areas and sleep-disordered breathing.Progress in brain research · 2014Review
- Leptin into the rostral ventral lateral medulla (RVLM) augments renal sympathetic nerve activity and blood pressure.Frontiers in neuroscience · 2014Article
- Leptin-sensitive sensory nerves innervate white fat.American journal of physiology. Endocrinology and metabolism · 2013Article
- Brainstem neuropeptides and vagal protection of the gastric mucosal against injury: role of prostaglandins, nitric oxide and calcitonin-gene related peptide in capsaicin afferents.Current medicinal chemistry · 2012Review
- Deficiency of PTP1B in POMC neurons leads to alterations in energy balance and homeostatic response to cold exposure.American journal of physiology. Endocrinology and metabolism · 2011Article
- Leptin amplifies the action of thyrotropin-releasing hormone in the solitary nucleus: an in vitro calcium imaging study.Brain research · 2011Article
- Temperatures rising: brown fat and bone.Discovery medicine · 2011Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
We have reported a highly cooperative interaction between leptin and thyrotropin releasing hormone (TRH) in the hindbrain to generate thermogenic responses (Hermann et al., 2006) (Rogers et al., 2009). Identifying the locus in the hindbrain where leptin and TRH act synergistically to increase thermogenesis will be necessary before we can determine the mechanism(s) by which this interaction occurs. Here, we performed heat-induced epitope recovery techniques and in situ hybridization to determine if neurons or afferent fibers in the hindbrain possess both TRH type 1 receptor and long-form leptin receptor [TRHR1; LepRb, respectively]. LepRb receptors were highly expressed in the solitary nucleus [NST], dorsal motor nucleus of the vagus [DMN] and catecholaminergic neurons of the ventrolateral medulla [VLM]. All neurons that contained LepRb also contained TRHR1. Fibers in the NST and the raphe pallidus [RP] and obscurrus [RO] that possess LepRb receptors were phenotypically identified as glutamatergic type 2 fibers (vglut2). Fibers in the NST and RP that possess TRHR1 receptors were phenotypically identified as serotonergic [i.e., immunopositive for the serotonin transporter; SERT]. Co-localization of LepRb and TRHR1 was not observed on individual fibers in the hindbrain but these two fiber types co-mingle in these nuclei. These anatomical arrangements may provide a basis for the synergy between leptin and TRH to increase thermogenesis.
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