ArticleBreast cancer research : BCR2010
Columnar cell lesions and subsequent breast cancer risk: a nested case-control study.
Article in Breast cancer research : BCR, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 61 citations in OpenAlex.
- Incidence of Adjacent Synchronous Ipsilateral Infiltrating Carcinoma and/or Ductal Carcinoma In Situ in Patients Diagnosed with Flat Epithelial Atypia by Core Needle Biopsy (TBCRC 034).Annals of surgical oncology · 2025Trial
- Benign Breast Disease and Breast Cancer Risk in the Percutaneous Biopsy Era.JAMA surgery · 2024Article
- A novel coiled-coil domain containing-related gene signature for predicting prognosis and treatment effect of breast cancer.Journal of cancer research and clinical oncology · 2023Article
- Are Columnar Cell Lesions the Earliest Non-Obligate Precursor in the Low-Grade Breast Neoplasia Pathway?Current oncology (Toronto, Ont.) · 2022Review
- Blunt duct adenosis: a separate entity from columnar cell lesions?Journal of clinical pathology · 2022Review
- Risk factors for breast cancer development by tumor characteristics among women with benign breast disease.Breast cancer research : BCR · 2021Article
- A whole slide image-based machine learning approach to predict ductal carcinoma in situ (DCIS) recurrence risk.Breast cancer research : BCR · 2019Article
- Sonographic Features of Flat Epithelial Atypia Manifesting as a Non-Mass-Like Lesion: A Case Report.The American journal of case reports · 2019Article
- Subtypes of Benign Breast Disease as a Risk Factor of Breast Cancer: A Systematic Review and Meta Analyses.Iranian journal of medical sciences · 2018Review
- How Do We Approach Benign Proliferative Lesions?Current oncology reports · 2018Review
- Flat epithelial atypia: conservative management of patients without residual microcalcifications post-vacuum-assisted breast biopsy.The British journal of radiology · 2018Observational
- Genetic analysis of microglandular adenosis and acinic cell carcinomas of the breast provides evidence for the existence of a low-grade triple-negative breast neoplasia family.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2017Article
- Article
- Management of flat epithelial atypia on breast core biopsy may be individualized based on correlation with imaging studies.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2015Article
- Persistent organic pollutants and obesity: are they potential mechanisms for breast cancer promotion?Endocrine-related cancer · 2015Review
- Benign breast disease and the risk of subsequent breast cancer in African American women.Cancer prevention research (Philadelphia, Pa.) · 2012Article
- Morphological parameters of flat epithelial atypia (FEA) in stereotactic vacuum-assisted needle core biopsies do not predict the presence of malignancy on subsequent surgical excision.Virchows Archiv : an international journal of pathology · 2012Article
- [Precursor lesions: epidemiology--is there enough evidence?].Der Pathologe · 2011Review
- Lifetime physical activity and the incidence of proliferative benign breast disease.Cancer causes & control : CCC · 2011Article
- Lobular neoplasia: frequency and association with other breast lesions.Diagnostic pathology · 2011Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
introductionHistologic and genetic evidence suggests that at least some columnar cell lesions (CCL) of the breast represent precursor lesions in the low-grade breast neoplasia pathway. However, the risk of subsequent breast cancer associated with the presence of CCL in a benign breast biopsy is poorly understood.
methodsThe authors examined the association between the presence of CCL and subsequent breast cancer risk in a nested case-control study of benign breast disease (BBD) and breast cancer within the Nurses' Health Studies (394 cases, 1,606 controls). Benign breast biopsy slides were reviewed by pathologists and CCL presence assessed. Logistic regression was used to compute odds ratios (ORs) and 95% confidence intervals (CIs) for the association between CCL and breast cancer risk.
resultsWomen with CCL (140 cases, 448 controls) had an increased risk of breast cancer compared with those without CCL (OR = 1.44, 95% CI: 1.14 to 1.83), although this was attenuated and became non-significant after adjustment for the histologic category of BBD (OR = 1.20, 95% CI: 0.94 to 1.54). CCL presence was associated with the greatest risk of breast cancer for those with nonproliferative BBD (OR = 1.36, 95% CI: 0.79 to 2.37) and the lowest risk for those with atypical hyperplasia (AH) (OR = 1.10, 95% CI: 0.65 to 1.87); however, this apparent heterogeneity in risk across BBD categories was not significant (P for interaction between CCL presence and BBD category = 0.77).
conclusionsThese results provide evidence that CCL may be an important marker of breast cancer risk in women with BBD but suggest that CCL do not increase breast cancer risk independently of concurrent proliferative changes in the breast.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.