ArticleAnalytical chemistry2010
Ion-selective permeability of an ultrathin nanoporous silicon membrane as probed by scanning electrochemical microscopy using micropipet-supported ITIES tips.
Article in Analytical chemistry, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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20 citing papers in PubMed, 74 citations in OpenAlex.
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- Nanoscale Hydrophobicity of Transport Barriers in the Nuclear Pore Complex as Compared with the Liquid/Liquid Interface by Scanning Electrochemical Microscopy.Analytical chemistry · 2025Article
- Use of the MicroSiM (µSiM) Barrier Tissue Platform for Modeling the Blood-Brain Barrier.Journal of visualized experiments : JoVE · 2024Article
- Nanoelectrochemistry at liquid/liquid interfaces for analytical, biological, and material applications.Chemical communications (Cambridge, England) · 2023Review
- Operando Scanning Electrochemical Probe Microscopy during Electrocatalysis.Chemical reviews · 2023Review
- Nanoelectrochemical Study of Molecular Transport through the Nuclear Pore Complex.Chemical record (New York, N.Y.) · 2021Review
- Microvascular Mimetics for the Study of Leukocyte-Endothelial Interactions.Cellular and molecular bioengineering · 2020Article
- Nanoscale electrostatic gating of molecular transport through nuclear pore complexes as probed by scanning electrochemical microscopy.Chemical science · 2019Article
- Probing High Permeability of Nuclear Pore Complexes by Scanning Electrochemical Microscopy: CaAnalytical chemistry · 2019Article
- Ultrathin Dual-Scale Nano- and Microporous Membranes for Vascular Transmigration Models.Small (Weinheim an der Bergstrasse, Germany) · 2019Article
- Finite element modeling to analyze TEER values across silicon nanomembranes.Biomedical microdevices · 2018Article
- Characterization of Nanopipet-Supported ITIES Tips for Scanning Electrochemical Microscopy of Single Solid-State Nanopores.Analytical chemistry · 2017Article
- Highly permeable silicon membranes for shear free chemotaxis and rapid cell labeling.Lab on a chip · 2014Article
- Ion permeability of the nuclear pore complex and ion-induced macromolecular permeation as studied by scanning electrochemical and fluorescence microscopy.Analytical chemistry · 2014Article
- High-performance, low-voltage electroosmotic pumps with molecularly thin silicon nanomembranes.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Electrochemical Sensing and Imaging Based on Ion Transfer at Liquid/Liquid Interfaces.Electrochimica acta · 2013Article
- Nanoscale mechanism of molecular transport through the nuclear pore complex as studied by scanning electrochemical microscopy.Journal of the American Chemical Society · 2013Article
- Quantitative imaging of ion transport through single nanopores by high-resolution scanning electrochemical microscopy.Journal of the American Chemical Society · 2012Article
- Stabilizing nanometer scale tip-to-substrate gaps in scanning electrochemical microscopy using an isothermal chamber for thermal drift suppression.Analytical chemistry · 2012Article
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Authors and funding
8 authors at 3 institutions in 1 country.
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Abstract
We report on the application of scanning electrochemical microscopy (SECM) to the measurement of the ion-selective permeability of porous nanocrystalline silicon membrane as a new type of nanoporous material with potential applications in analytical, biomedical, and biotechnology device development. The reliable measurement of high permeability in the molecularly thin nanoporous membrane to various ions is important for greater understanding of its structure-permeability relationship and also for its successful applications. In this work, this challenging measurement is enabled by introducing two novel features into amperometric SECM tips based on the micropipet-supported interface between two immiscible electrolyte solutions (ITIES) to reveal the important ion-transport properties of the ultrathin nanopore membrane. The tip of a conventional heat-pulled micropipet is milled using the focused ion beam (FIB) technique to be smoother, better aligned, and subsequently, approach closer to the membrane surface, which allows for more precise and accurate permeability measurement. The high membrane permeability to small monovalent ions is determined using FIB-milled micropipet tips to establish a theoretical formula for the membrane permeability that is controlled by free ion diffusion across water-filled nanopores. Moreover, the ITIES tips are rendered selective for larger polyions with biomedical importance, i.e., polyanionic pentasaccharide Arixtra and polycationic peptide protamine, to yield the membrane permeability that is lower than the corresponding diffusion-limited permeability. The hindered transport of the respective polyions is unequivocally ascribed to electrostatic and steric repulsions from the wall of the nanopores, i.e., the charge and size effects.
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