ArticleHuman brain mapping2011
Increased "default mode" activity in adolescents prenatally exposed to cocaine.
Article in Human brain mapping, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.
- Pooled it
- Caregiving Environmental Risk and Aggression From Infancy to Adolescence in a High-Risk Sample: An Examination of Between-Family and Within-Family Effects.Aggressive behavior · 2025Article
- Prenatal Substance Exposure.Annual review of developmental psychology · 2023Article
- Longitudinal changes of amygdala functional connectivity in adolescents prenatally exposed to cocaine.Drug and alcohol dependence · 2019Article
- Resting State Functional Connectivity of the Lateral and Medial Hypothalamus in Cocaine Dependence: An Exploratory Study.Frontiers in psychiatry · 2018Article
- Altered functional connectivity to stressful stimuli in prenatally cocaine-exposed adolescents.Drug and alcohol dependence · 2017Article
- Inflammation is associated with decreased functional connectivity within corticostriatal reward circuitry in depression.Molecular psychiatry · 2016Article
- Cocaine dependence and thalamic functional connectivity: a multivariate pattern analysis.NeuroImage. Clinical · 2016Article
- Executive function and cortical thickness in youths prenatally exposed to cocaine, alcohol and tobacco.Developmental cognitive neuroscience · 2015Article
- Prenatal drug exposure affects neonatal brain functional connectivity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Effect of cocaine dependence on brain connections: clinical implications.Expert review of neurotherapeutics · 2015Review
- Prenatal cocaine exposure and adolescent neural responses to appetitive and stressful stimuli.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2014Article
- Neurobehavioral and Developmental Traiectories Associated with Level of Prenatal Cocaine Exposure.Journal of neurology and psychology · 2014Article
- Prenatal cocaine effects on brain structure in early infancy.NeuroImage · 2014Article
- Review
- Child Behavior Problems: Role of Cocaine Use, Parenting and Child Exposure to Violence.Psychology of violence · 2014Article
- Prenatal cocaine exposure and trajectories of externalizing behavior problems in early childhood: examining the role of maternal negative affect.Development and psychopathology · 2014Article
- Externalizing behavior problems among polydrug cocaine-exposed children: Indirect pathways via maternal harshness and self-regulation in early childhood.Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors · 2014Article
- Stochastic dynamic causal modeling of working memory connections in cocaine dependence.Human brain mapping · 2014Article
- Default mode network activity in male adolescents with conduct and substance use disorder.Drug and alcohol dependence · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Prenatal cocaine exposure (PCE) is associated with attention/arousal dysregulation and possible inefficiencies in some cognitive functions. However, the neurobiological bases of these teratogenic effects have not been well characterized. Because activities in the default mode network (DMN) reflect intrinsic brain functions that are closely associated with arousal regulation and cognition, alterations in the DMN could underlie cognitive effects related to PCE. With resting-state and task activation functional magnetic resonance imaging (fMRI), this study investigated the possible PCE related changes in functional brain connectivity and brain activation in the DMN. In the resting state, the PCE group was found to have stronger functional connectivity in the DMN, as compared to the nonexposed controls. During a working memory task with emotional distracters, the PCE group exhibited less deactivation in the DMN and their fMRI signal was more increased by emotional arousal. These data revealed additional neural effects related to PCE, and consistent with previous findings, indicate that PCE may affect behavior and functioning by increasing baseline arousal and altering the excitatory/inhibitory balancing mechanisms involved in cognitive resource allocation.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.