ArticleJournal of structural and functional genomics2010
The New York Consortium on Membrane Protein Structure (NYCOMPS): a high-throughput platform for structural genomics of integral membrane proteins.
Article in Journal of structural and functional genomics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed.
- Functional role of a structural water in the elevator domain of dicarboxylate transporter VcINDY.PNAS nexus · 2026Article
- Designer artificial environments for membrane protein synthesis.Nature communications · 2025Article
- Structure and selectivity of a glutamate-specific TAXI TRAP binding protein from Vibrio cholerae.The Journal of general physiology · 2024Article
- Facing the phase problem.IUCrJ · 2023Article
- Insight into the mechanism of HProceedings of the National Academy of Sciences of the United States of America · 2023Article
- Structural basis of ion - substrate coupling in the NaNature communications · 2022Article
- Thermostability-based binding assays reveal complex interplay of cation, substrate and lipid binding in the bacterial DASS transporter, VcINDY.The Biochemical journal · 2021Article
- Fine Sampling of Sequence Space for Membrane Protein Structural Biology.Journal of molecular biology · 2021Article
- Solvent accessibility changes in a NaThe Journal of biological chemistry · 2020Article
- Article
- Cryo-EM structure of arabinosyltransferase EmbB from Mycobacterium smegmatis.Nature communications · 2020Article
- Cryo-EM Structures and Regulation of Arabinofuranosyltransferase AftD from Mycobacteria.Molecular cell · 2020Article
- TMCrys: predict propensity of success for transmembrane protein crystallization.Bioinformatics (Oxford, England) · 2018Article
- Article
- A statistical model for improved membrane protein expression using sequence-derived features.The Journal of biological chemistry · 2018Article
- TMSEG: Novel prediction of transmembrane helices.Proteins · 2016Article
- Atomic-level analysis of membrane-protein structure.Nature structural & molecular biology · 2016Review
- The bacterial dicarboxylate transporter VcINDY uses a two-domain elevator-type mechanism.Nature structural & molecular biology · 2016Article
- Structure of a membrane-embedded prenyltransferase homologous to UBIAD1.PLoS biology · 2014Article
- Functional characterization of a Na+-dependent dicarboxylate transporter from Vibrio cholerae.The Journal of general physiology · 2014Article
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17 authors.
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Abstract
The New York Consortium on Membrane Protein Structure (NYCOMPS) was formed to accelerate the acquisition of structural information on membrane proteins by applying a structural genomics approach. NYCOMPS comprises a bioinformatics group, a centralized facility operating a high-throughput cloning and screening pipeline, a set of associated wet labs that perform high-level protein production and structure determination by x-ray crystallography and NMR, and a set of investigators focused on methods development. In the first three years of operation, the NYCOMPS pipeline has so far produced and screened 7,250 expression constructs for 8,045 target proteins. Approximately 600 of these verified targets were scaled up to levels required for structural studies, so far yielding 24 membrane protein crystals. Here we describe the overall structure of NYCOMPS and provide details on the high-throughput pipeline.
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