ArticlePsychopharmacology2010
GABA(A) ρ receptor mechanisms in the rat amygdala and its role in the modulation of fear and anxiety.
Article in Psychopharmacology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
10 citing papers in PubMed, 24 citations in OpenAlex.
- Selecting an appropriate stress model of depression in rodents.World journal of psychiatry · 2025Review
- Elevated Level of PKMζ Underlies the Excessive Anxiety in an Autism Model.Frontiers in molecular neuroscience · 2019Article
- Differential modulation of human GABABMC neuroscience · 2018Article
- GABAPhysiological reports · 2017Article
- Functional characterization of neurotransmitter activation and modulation in a nematode model ligand-gated ion channel.Journal of neurochemistry · 2016Article
- Amygdala NRG1-ErbB4 is critical for the modulation of anxiety-like behaviors.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2015Article
- Seeking structural specificity: direct modulation of pentameric ligand-gated ion channels by alcohols and general anesthetics.Pharmacological reviews · 2014Review
- GABAA receptors containing ρ1 subunits contribute to in vivo effects of ethanol in mice.PloS one · 2014Article
- Dopamine and serotonin modulate human GABAρ1 receptors expressed in Xenopus laevis oocytes.ACS chemical neuroscience · 2012Article
- GABA(A) ρ receptor mechanisms in the rat amygdala and its role in the modulation of fear and anxiety.Psychopharmacology · 2010Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
rationaleAccumulating evidence for the presence of GABA(A) ρ receptors within the amygdala which differ from other members of the GABA(A) receptor family in both subunit composition and functional properties has been recently obtained.
objectivesThis work was conducted to study whether GABA(A) ρ receptors may have a putative role in the amygdaloid modulation of fear and anxiety.
resultsIt was found that the bilateral intra-amygdaloid administration (6-240 pmol/side) of (1,2,5,6-tetrahydropyridine-4-yl)methylphosphinic acid, a selective GABA(A) ρ receptor antagonist, reduced dose-dependently the exploration of the open arms of the elevated plus-maze without affecting locomotion and increased the plasma levels of corticosterone. In contrast, bicuculline in the dose range used (1.8-60 pmol/side) induced seizures, but had no effects on the exploration of the maze.
conclusionsIt is suggested that GABA(A) ρ receptors may have a role in the amygdaloid modulation of fear and anxiety.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.