SynthesisPLoS neglected tropical diseases2010
Etiology of diarrhea in older children, adolescents and adults: a systematic review.
Synthesis in PLoS neglected tropical diseases, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 82 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
82 citing papers in PubMed, 4 syntheses or guidelines pooled it, 145 citations in OpenAlex.
- National, regional, and global causes of mortality in 5-19-year-olds from 2000 to 2019: a systematic analysis.The Lancet. Global health · 2022Pooled it
- Pooled it
- Understanding the Impact of Rainfall on Diarrhea: Testing the Concentration-Dilution Hypothesis Using a Systematic Review and Meta-Analysis.Environmental health perspectives · 2020Pooled it
- Estimating diarrheal illness and deaths attributable to Shigellae and enterotoxigenic Escherichia coli among older children, adolescents, and adults in South Asia and Africa.PLoS neglected tropical diseases · 2014Pooled it
- Determinants of diarrheal diseases among patients attending public health centers in Addis Ababa and Hossana, Ethiopia: a matched case-control study.Tropical medicine and health · 2025Article
- Etiological, Clinical, and Epidemiological Characteristics of Acute Viral Gastroenteritis in an Adult Population in a Tertiary Level Hospital in Spain.Infectious diseases and therapy · 2025Article
- Occurrence of enterotoxigenicFrontiers in environmental science · 2025Article
- Microbiota and metabolome dynamics induced by Shiga toxin-producingMicrobial cell (Graz, Austria) · 2025Article
- Tryptophan Metabolism in Alzheimer's Disease with the Involvement of Microglia and Astrocyte Crosstalk and Gut-Brain Axis.Aging and disease · 2024Review
- Article
- A comparison of the NIRUDAK models and WHO algorithm for dehydration assessment in older children and adults with acute diarrhoea: a prospective, observational study.The Lancet. Global health · 2023Observational
- Integrated traditional herbal medicine in the treatment of gastrointestinal disorder: the pattern of use and the knowledge of safety among the Eastern Region Saudi population.BMC complementary medicine and therapies · 2023Article
- Derivation and External Validation of a Clinical Prediction Model for Viral Diarrhea Etiology in Bangladesh.Open forum infectious diseases · 2023Article
- Understanding variations in diarrhea management across healthcare facilities in Bangladesh: a formative qualitative study.Journal of infection in developing countries · 2023Article
- Plant-Derived Products with Therapeutic Potential against Gastrointestinal Bacteria.Pathogens (Basel, Switzerland) · 2023Review
- Development, Optimisation and Validation of a Novel Multiplex Real-Time PCR Method for the Simultaneous Detection ofPathogens (Basel, Switzerland) · 2022Article
- Article
- High Prevalence of Beta-Lactam-ResistantMicroorganisms · 2022Article
- Anti-Diarrheal Activities of Hydromethanolic Crude Extract and Solvent Fractions ofClinical pharmacology : advances and applications · 2022Article
- Assessing the performance of clinical diagnostic models for dehydration among patients with cholera and undernutrition in Bangladesh.Tropical medicine & international health : TM & IH · 2021Article
22 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDiarrhea is an important cause of morbidity and mortality in all regions of the world and among all ages, yet little is known about the fraction of diarrhea episodes and deaths due to each pathogen. METHODOLOGY/PRINCIPAL
findingsWe conducted a systematic literature review to identify all papers reporting the proportion of diarrhea episodes with positive laboratory tests for at least one pathogen in inpatient, outpatient and community settings that met our inclusion and exclusion criteria. We identified a total of 25,701 papers with possible etiology data and after final screening included 22 papers that met all inclusion and exclusion criteria. Enterotoxigenic Escherichia coli and V. cholerae O1/O139 were the leading causes of hospitalizations. In outpatient settings, Salmonella spp., Shigella spp., and E. histolytica were the most frequently isolated pathogens. CONCLUSIONS/SIGNIFICANCE: This is the first systematic review which has considered the relative importance of multiple diarrhea pathogens. The few studies identified suggest that there is a great need for additional prospective studies around the world in these age groups to better understand the burden of disease and the variation by region.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.