ArticleNature medicine2010
Glutamate joins the ranks of immunomodulators.
Article in Nature medicine, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Systems-level transcriptomic analysis reveals synapse-related gene dysregulation in peripheral leukocytes of MDD patients.Scientific reports · 2026Pooled it
- Pathway thermodynamic analysis postulates change in glutamate metabolism as a key factor in modulating immune responses.Immunometabolism (Cobham, Surrey) · 2026Article
- Modulating glutamate neurotransmission inFrontiers in immunology · 2026Review
- HUBMet: an integrative database and analytical platform for human blood metabolites and metabolite-protein associations.Genome biology · 2025Article
- Not Just Neurons: Pain Is Orchestrated in Partnership with Many Non-neuronal Cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Review
- Article
- Metabolomic and lipidomic signatures associated with activation of human cDC1 (BDCA3Immunology · 2022Article
- Glutamate metabolism directs energetic trade-offs to shape host-pathogen susceptibility in Drosophila.Cell metabolism · 2021Article
- Short Communication: Differences in Levels of Free Amino Acids and Total Protein in Human Foremilk and Hindmilk.Nutrients · 2018Article
- Article
- Role of Neurochemicals in the Interaction between the Microbiota and the Immune and the Nervous System of the Host Organism.Probiotics and antimicrobial proteins · 2017Review
- Prevention and treatment of cancers by immune modulating nutrients.Molecular nutrition & food research · 2016Review
- Allosteric modulation of metabotropic glutamate receptor 4 activates IDO1-dependent, immunoregulatory signaling in dendritic cells.Neuropharmacology · 2016Article
- Systems biological approaches to measure and understand vaccine immunity in humans.Seminars in immunology · 2013Review
- The role of glutamate and the immune system in organophosphate-induced CNS damage.Neurotoxicity research · 2013Review
- Good news-bad news: the Yin and Yang of immune privilege in the eye.Frontiers in immunology · 2012Article
- Metabotropic glutamate receptors: from the workbench to the bedside.Neuropharmacology · 2011Review
- Clinical correlates for immune checkpoint therapy: significance for CNS malignancies.Neuro-oncology advancesReview
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
PubMed holds no abstract for this paper.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.