ArticleAmerican journal of physiology. Gastrointestinal and liver physiology2010
Identification of microRNAs during rat liver regeneration after partial hepatectomy and modulation by ursodeoxycholic acid.
Article in American journal of physiology. Gastrointestinal and liver physiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
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Who cites it
50 citing papers in PubMed, 91 citations in OpenAlex.
- Ursodeoxycholic acid: Effects on hepatic unfolded protein response, apoptosis and oxidative stress in morbidly obese patients.Liver international : official journal of the International Association for the Study of the Liver · 2018Trial
- Bile Acid Application in Cell-Targeting for Molecular Receptors in Relation to Hearing: A Comprehensive Review.Current drug targets · 2024Review
- Article
- Diverse MicroRNAs-mRNA networks regulate the priming phase of mouse liver regeneration and of direct hyperplasia.Cell proliferation · 2022Article
- Liver Regeneration: Changes in Oxidative Stress, Immune System, Cytokines, and Epigenetic Modifications Associated with Aging.Oxidative medicine and cellular longevity · 2022Review
- Article
- Molecular pathways of liver regeneration: A comprehensive review.World journal of hepatology · 2021Review
- Article
- Ursodeoxycholic acid inhibits intimal hyperplasia, vascular smooth muscle cell excessive proliferation, migration via blocking miR-21/PTEN/AKT/mTOR signaling pathway.Cell cycle (Georgetown, Tex.) · 2020Article
- Partial hepatectomy‑induced upregulation of SNHG12 promotes hepatocyte proliferation and liver regeneration.Molecular medicine reports · 2020Article
- Comprehensive analysis of lncRNA-miRNA-mRNA during proliferative phase of rat liver regeneration.Journal of cellular physiology · 2019Article
- Role of bile acids in colon carcinogenesis.World journal of clinical cases · 2018Review
- A Novel Oncolytic Herpes Simplex Virus Design based on the Common Overexpression of microRNA-21 in Tumors.Journal of gene therapy · 2018Article
- MiR-27a/b Regulates Liver Regeneration by Posttranscriptional Modification of Tmub1.Digestive diseases and sciences · 2018Article
- Post-hepatectomy liver regeneration in the context of bile acid homeostasis and the gut-liver signaling axis.Journal of clinical and translational research · 2018Article
- miRNA-21 ablation protects against liver injury and necroptosis in cholestasis.Cell death and differentiation · 2018Article
- Liver Regeneration in the Acute Liver Failure Patient.Clinics in liver disease · 2018Review
- Activation of miR-34a impairs autophagic flux and promotes cochlear cell death via repressing ATG9A: implications for age-related hearing loss.Cell death & disease · 2017Article
- Novel circulating- and imaging-based biomarkers to enhance the mechanistic understanding of human drug-induced liver injury.Journal of clinical and translational research · 2017Review
- The role of lncRNA MALAT1 in the regulation of hepatocyte proliferation during liver regeneration.International journal of molecular medicine · 2017Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
Abstract
New gene regulation study tools such as microRNA (miRNA or miR) analysis may provide unique insights into the remarkable ability of the liver to regenerate. In addition, we have previously shown that ursodeoxycholic acid (UDCA) modulates mRNA levels during liver regeneration. Bile acids are also homeotrophic sensors of functional hepatic capacity. The present study was designed to determine whether miRNAs are modulated in rats following 70% partial hepatectomy (PH) and elucidate the role of UDCA in regulating miRNA expression during liver regeneration (LR). Total RNA was isolated from livers harvested at 3-72 h following 70% PH or sham operations, from both 0.4% (wt/wt) UDCA and control diet-fed animals. By using a custom microarray platform we found that several miRNAs are significantly altered after PH by >1.5-fold, including some previously described as modulators of cell proliferation, differentiation, and death. In particular, expression of miR-21 was increased after PH. Functional modulation of miR-21 in primary rat hepatocytes increased cell proliferation and viability. Importantly, UDCA was a strong inducer of miR-21 both during LR and in cultured HepG2 cells. In fact, UDCA feeding appeared to induce a sustained increase of proliferative miRNAs observed at early time points after PH. In conclusion, miRNAs, in particular miR-21, may play a significant role in modulating proliferation and cell cycle progression genes after PH. miR-21 is additionally induced by UDCA in both regenerating rat liver and in vitro, which may represent a new mechanism behind UDCA biological functions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.