ArticleJournal of the American Society of Nephrology : JASN2010
Overexpression of VEGF165b in podocytes reduces glomerular permeability.
Article in Journal of the American Society of Nephrology : JASN, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 42 citations in OpenAlex.
- Glomerular ultrastructural change and vascular endothelial growth factor-A expression in diabetic cats.The Journal of small animal practice · 2025Article
- The unique structural and functional characteristics of glomerular endothelial cell fenestrations and their potential as a therapeutic target in kidney disease.American journal of physiology. Renal physiology · 2023Review
- Ion channels and channelopathies in glomeruli.Physiological reviews · 2023Review
- Salivary levels and immunohistochemical expression of selected angiogenic factors in benign and malignant parotid gland tumours.Clinical oral investigations · 2019Article
- The natural drug DIAVIT is protective in a type II mouse model of diabetic nephropathy.PloS one · 2019Article
- Modulation of VEGF-A Alternative Splicing as a Novel Treatment in Chronic Kidney Disease.Genes · 2018Review
- Article
- VEGF-AThe Journal of physiology · 2017Article
- VEGF as a Paracrine Regulator of Conventional Outflow Facility.Investigative ophthalmology & visual science · 2017Article
- Antiangiogenic Therapy for Diabetic Nephropathy.BioMed research international · 2017Review
- Vascular Growth Factors and Glomerular Disease.Annual review of physiology · 2016Review
- Vascular Endothelial Growth Factor-A165b Is Protective and Restores Endothelial Glycocalyx in Diabetic Nephropathy.Journal of the American Society of Nephrology : JASN · 2015Article
- Xuebijing exerts protective effects on lung permeability leakage and lung injury by upregulating Toll-interacting protein expression in rats with sepsis.International journal of molecular medicine · 2014Article
- VEGF-A165b is an endogenous neuroprotective splice isoform of vascular endothelial growth factor A in vivo and in vitro.The American journal of pathology · 2013Article
- VEGF165b overexpression restores normal glomerular water permeability in VEGF164-overexpressing adult mice.American journal of physiology. Renal physiology · 2012Article
- VEGFA family isoforms regulate spermatogonial stem cell homeostasis in vivo.Endocrinology · 2012Article
- WT1 mutants reveal SRPK1 to be a downstream angiogenesis target by altering VEGF splicing.Cancer cell · 2011Article
- Induction of podocyte-derived VEGF ameliorates podocyte injury and subsequent abnormal glomerular development caused by puromycin aminonucleoside.Pediatric research · 2011Article
- Endothelial factors and diabetic nephropathy.Diabetes care · 2011Article
- Biophysical properties of normal and diseased renal glomeruli.American journal of physiology. Cell physiology · 2011Article
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Authors and funding
13 authors at 1 institution.
Funding
Abstract
The observation that therapeutic agents targeting vascular endothelial growth factor-A (VEGF-A) associate with renal toxicity suggests that VEGF plays a role in the maintenance of the glomerular filtration barrier. Alternative mRNA splicing produces the VEGF(xxx)b family, which consists of antiangiogenic peptides that reduce permeability and inhibit tumor growth; the contribution of these peptides to normal glomerular function is unknown. Here, we established and characterized heterozygous and homozygous transgenic mice that overexpress VEGF(165)b specifically in podocytes. We confirmed excess production of glomerular VEGF(165)b by reverse transcriptase-PCR, immunohistochemistry, and ELISA in both heterozygous and homozygous animals. Macroscopically, the mice seemed normal up to 18 months of age, unlike the phenotype of transgenic podocyte-specific VEGF(164)-overexpressing mice. Animals overexpressing VEGF(165)b, however, had a significantly reduced normalized glomerular ultrafiltration fraction with accompanying changes in ultrastructure of the glomerular filtration barrier on the vascular side of the glomerular basement membrane. These data highlight the contrasting properties of VEGF splice variants and their impact on glomerular function and phenotype.
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