Evidence map›Paper›PMID 20688781›Full record

ArticleEuropean heart journal2010

Vitamin D deficiency is associated with sudden cardiac death, combined cardiovascular events, and mortality in haemodialysis patients.

Christiane Drechsler, Stefan Pilz, Barbara Obermayer-Pietsch, Marion Verduijn, Andreas Tomaschitz, Vera Krane, Katharina Espe, Friedo Dekker, Vincent Brandenburg, Winfried März and 2 more

Registry-linked trialOpen access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European heart journal, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01774812 (Vitamin D Supplementation and Cardiac Autonomic Tone in Hemodialysis Patients), which is not on this map. Cited by 107 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
107citing papers in PubMed, 6 pooled it
15.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01774812 phase2completednot on this mapstarted 2013, after this paper: background citation

Vitamin D Supplementation and Cardiac Autonomic Tone in Hemodialysis Patients: A Blinded, Randomized-controlled Trial

TypeinterventionalSponsorUniversity of CalgaryRan2013 to 2015Enrolled56ConditionsCardiovascular Disease, Sudden Cardiac DeathArmsAlfacalcidol, Ergocalciferol
3 · Its place in the literature

Who cites it

107 citing papers in PubMed, 6 syntheses or guidelines pooled it, 259 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
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  5. Active vitamin D treatment for reduction of residual proteinuria: a systematic review.Journal of the American Society of Nephrology : JASN · 2013
    Pooled it
  6. Pooled it
  7. Trial
  8. Trial
  9. Long-term cholecalciferol administration in hemodialysis patients: a single-center randomized pilot study.Medical science monitor : international medical journal of experimental and clinical research · 2014
    Trial
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  12. Effect of paricalcitol on left ventricular mass and function in CKD--the OPERA trial.Journal of the American Society of Nephrology : JASN · 2014
    Trial
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  14. Trial
  15. Trial
  16. Trial
  17. Review
  18. Article
  19. Article
  20. Review

47 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 3 countries.

Christiane DrechslerDepartment of Internal Medicine 1, Division of Nephrology, University of Würzburg, Oberdürrbacher Str. 6, D-97080 Würzburg, Germany. c.drechsler@gmx.net
Stefan Pilz
Barbara Obermayer-Pietsch
Marion Verduijn
Andreas Tomaschitz
Vera Krane
Katharina Espe
Friedo Dekker
Vincent Brandenburg
Winfried März
Eberhard Ritz
Christoph Wanner
Medical University of Graz · ATUniversity of Würzburg · DELeiden University Medical Center · NLHeidelberg University · DERWTH Aachen University · DEUniversity of Potsdam · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsDialysis patients experience an excess mortality, predominantly of sudden cardiac death (SCD). Accumulating evidence suggests a role of vitamin D for myocardial and overall health. This study investigated the impact of vitamin D status on cardiovascular outcomes and fatal infections in haemodialysis patients. METHODS AND

results25-hydroxyvitamin D [25(OH)D] was measured in 1108 diabetic haemodialysis patients who participated in the German Diabetes and Dialysis Study and were followed up for a median of 4 years. By Cox regression analyses, we determined hazard ratios (HR) for pre-specified, adjudicated endpoints according to baseline 25(OH)D levels: SCD (n = 146), myocardial infarction (MI, n = 174), stroke (n = 89), cardiovascular events (CVE, n = 414), death due to heart failure (n = 37), fatal infection (n = 111), and all-cause mortality (n = 545). Patients had a mean age of 66 ± 8 years (54% male) and median 25(OH)D of 39 nmol/L (interquartile range: 28-55). Patients with severe vitamin D deficiency [25(OH)D of ≤ 25 nmol/L] had a 3-fold higher risk of SCD compared with those with sufficient 25(OH)D levels >75 nmol/L [HR: 2.99, 95% confidence interval (CI): 1.39-6.40]. Furthermore, CVE and all-cause mortality were strongly increased (HR: 1.78, 95% CI: 1.18-2.69, and HR: 1.74, 95% CI: 1.22-2.47, respectively), all persisting in multivariate models. There were borderline non-significant associations with stroke and fatal infection while MI and deaths due to heart failure were not meaningfully affected.

conclusionSevere vitamin D deficiency was strongly associated with SCD, CVE, and mortality, and there were borderline associations with stroke and fatal infection. Whether vitamin D supplementation decreases adverse outcomes requires further evaluation.

Indexed as

AdultAgedAged, 80 and overDeath, Sudden, CardiacDiabetic AngiopathiesDiabetic NephropathiesFemaleHeart FailureHumansInfectionsMaleMiddle AgedMyocardial InfarctionRenal DialysisRisk FactorsStroke25-hydroxyvitamin DVitamin D

Identifiers

PMID20688781
PMCPMC2938469
OpenAlexW2059531072

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.