ArticleDental materials : official publication of the Academy of Dental Materials2010
A chemical phosphorylation-inspired design for Type I collagen biomimetic remineralization.
Article in Dental materials : official publication of the Academy of Dental Materials, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 80 citations in OpenAlex.
- Methods for biomimetic remineralization of human dentine: a systematic review.International journal of molecular sciences · 2015Pooled it
- The use of sodium trimetaphosphate as a biomimetic analog of matrix phosphoproteins for remineralization of artificial caries-like dentin.Dental materials : official publication of the Academy of Dental Materials · 2011Trial
- Calcium ionic replacement in sodium trimetaphosphate particles: a novel strategy for bone tissue engineering.Journal of materials science. Materials in medicine · 2026Article
- Comparative evaluation of the remineralisation potential of biomimetic agents on phosphorylated dentine using SEM-EDX analysis: an in vitro study.Biomaterial investigations in dentistry · 2026Article
- Synthesis, Characterization, and Evaluation of the Antimicrobial Effects and Cytotoxicity of a Novel Nanocomposite Based on Polyamide 6 and Trimetaphosphate Nanoparticles Decorated with Silver Nanoparticles.Antibiotics (Basel, Switzerland) · 2024Article
- Remineralization of Dentinal Lesions Using Biomimetic Agents: A Systematic Review and Meta-Analysis.Biomimetics (Basel, Switzerland) · 2023Review
- The Effect of Polyacrylic Acid and Sodium Trimetaphosphate on Dentin Hybrid Layer Remineralization: AnJournal of clinical and experimental dentistry · 2022Article
- Promoting effect of a calcium-responsive self-assembly β-sheet peptide on collagen intrafibrillar mineralization.Regenerative biomaterials · 2022Article
- The effects of washing a collagen sample prior to TEM examination.Microscopy research and technique · 2022Article
- Advances in biomineralization-inspired materials for hard tissue repair.International journal of oral science · 2021Review
- Mineralization of Phosphorylated Fish Skin Collagen/Mangosteen Scaffolds as Potential Materials for Bone Tissue Regeneration.Molecules (Basel, Switzerland) · 2021Article
- Biomimetic Aspects of Oral and Dentofacial Regeneration.Biomimetics (Basel, Switzerland) · 2020Review
- Use of tendon to produce decellularized sheets of mineralized collagen fibrils for bone tissue repair and regeneration.Journal of biomedical materials research. Part B, Applied biomaterials · 2020Article
- Effects of Polyacrylic Acid Pre-Treatment on Bonded-Dentine Interfaces Created with a Modern Bioactive Resin-Modified Glass Ionomer Cement and Subjected to Cycling Mechanical Stress.Materials (Basel, Switzerland) · 2018Article
- A novel oligopeptide simulating dentine matrix protein 1 for biomimetic mineralization of dentine.Clinical oral investigations · 2014Article
- Biomimetic remineralization of dentin.Dental materials : official publication of the Academy of Dental Materials · 2014Article
- Durable bonds at the adhesive/dentin interface: an impossible mission or simply a moving target?Brazilian dental science · 2012Article
- Hierarchical and non-hierarchical mineralisation of collagen.Biomaterials · 2011Article
Corrections and comments
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Authors and funding
8 authors at 6 institutions in 3 countries.
Funding
Abstract
objectivesType I collagen alone cannot initiate tissue mineralization. Sodium trimetaphosphate (STMP) is frequently employed as a chemical phosphorylating reagent in the food industry. This study examined the feasibility of using STMP as a functional analog of matrix phosphoproteins for biomimetic remineralization of resin-bonded dentin.
methodsEquilibrium adsorption and desorption studies of STMP were performed using demineralized dentin powder (DDP). Interaction between STMP and DDP was examined using Fourier transform-infrared spectroscopy. Based on those results, a bio-inspired mineralization scheme was developed for chemical phosphorylation of acid-etched dentin with STMP, followed by infiltration of the STMP-treated collagen matrix with two etch-and-rinse adhesives. Resin-dentin interfaces were remineralized in a Portland cement-simulated body fluid system, with or without the use of polyacrylic acid (PAA) as a dual biomimetic analog. Remineralized resin-dentin interfaces were examined unstained using transmission electron microscopy.
resultsAnalysis of saturation binding curves revealed the presence of irreversible phosphate group binding sites on the surface of the DDP. FT-IR provided additional evidence of chemical interaction between STMP and DDP, with increased in the peak intensities of the PO and P-O-C stretching modes. Those peaks returned to their original intensities after alkaline phosphatase treatment. Evidence of intrafibrillar apatite formation could be seen in incompletely resin-infiltrated, STMP-phosphorylated collagen matrices only when PAA was present in the SBF. SIGNIFICANCE: These results reinforce the importance of PAA for sequestration of amorphous calcium phosphate nanoprecursors in the biomimetic remineralization scheme. They also highlight the role of STMP as a templating analog of dentin matrix phosphoproteins for inducing intrafibrillar remineralization of apatite nanocrystals within the collagen matrix of incompletely resin-infiltrated dentin.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.