ReviewSeminars in cell & developmental biology2010
Pancreatic beta-cells: from generation to regeneration.
Review in Seminars in cell & developmental biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed.
- Antihyperglycemic and anti-type 2 diabetic activity of marine hydroquinone isolated from brown algae (Journal of traditional and complementary medicine · 2023Article
- Verification of the folkloric and anecdotal antidiabetic effects of Hypoxis hemerocallidea (Fisch., C.A. Mey. & Avé-Lall) and isolated, β-sitosterol using early-stage type II spontaneous diabetic mutant BKS-LeprBMC complementary medicine and therapies · 2022Article
- The Eye as a Transplantation Site to Monitor Pancreatic Islet Cell Plasticity.Frontiers in endocrinology · 2021Review
- Pathological Mechanisms in Diabetes of the Exocrine Pancreas: What's Known and What's to Know.Frontiers in physiology · 2020Review
- Improvement of Insulin Secretion and Pancreatic β-cell Function in Streptozotocin-induced Diabetic Rats Treated withPharmacognosy research · 2017Article
- β-cell replacement sources for type 1 diabetes: a focus on pancreatic ductal cells.Therapeutic advances in endocrinology and metabolism · 2016Review
- Evolving function and potential of pancreatic alpha cells.Best practice & research. Clinical endocrinology & metabolism · 2015Review
- Progenitor Epithelium: Sorting Out Pancreatic Lineages.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2015Review
- Metabolic regulation and energy homeostasis through the primary Cilium.Cell metabolism · 2015Review
- Delta Cell Hyperplasia in Adult Goto-Kakizaki (GK/MolTac) Diabetic Rats.Journal of diabetes research · 2015Article
- Non-neural tyrosine hydroxylase, via modulation of endocrine pancreatic precursors, is required for normal development of beta cells in the mouse pancreas.Diabetologia · 2014Article
- Islets of Langerhans from prohormone convertase-2 knockout mice show α-cell hyperplasia and tumorigenesis with elevated α-cell neogenesis.International journal of experimental pathology · 2014Article
- A genetic mouse model for progressive ablation and regeneration of insulin producing beta-cells.Cell cycle (Georgetown, Tex.) · 2014Article
- How to make a functional β-cell.Development (Cambridge, England) · 2013Review
- Article
- Islet-derived stem cells from adult rats participate in the repair of islet damage.Journal of molecular histology · 2012Article
- The ontogeny of the endocrine pancreas in the fetal/newborn baboon.The Journal of endocrinology · 2012Article
- Generation of beta cells from human pluripotent stem cells: Potential for regenerative medicine.Seminars in cell & developmental biology · 2012Review
- Crosstalk between the developing pancreas and its blood vessels: an evolving dialog.Seminars in cell & developmental biology · 2012Review
- Deconstructing pancreas developmental biology.Cold Spring Harbor perspectives in biology · 2012Review
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
The pancreas is composed of two main compartments consisting of endocrine and exocrine tissues. The majority of the organ is exocrine and responsible for the synthesis of digestive enzymes and for their transport via an intricate ductal system into the duodenum. The endocrine tissue represents less than 2% of the organ and is organized into functional units called islets of Langerhans, comprising alpha-, beta-, delta-, epsilon- and PP-cells, producing the hormones glucagon, insulin, somatostatin, ghrelin and pancreatic polypeptide (PP), respectively. Insulin-producing beta-cells play a central role in the control of the glucose homeostasis. Accordingly, absolute or relative deficiency in beta-cells may ultimately lead to type 1 and/or type 2 diabetes, respectively. One major goal of diabetes research is therefore to understand the molecular mechanisms controlling the development of beta-cells during pancreas morphogenesis, but also those underlying the regeneration of adult injured pancreas, and assess their significance for future cell-based therapy. In this review, we will therefore present new insights into beta-cell development with focus on beta-cell regeneration.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.