ArticleNeurobiology of disease2010
Cerebral cortex structure in prodromal Huntington disease.
Article in Neurobiology of disease, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers, 1 of them a synthesis that pooled it.
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Who cites it
65 citing papers in PubMed, 1 synthesis or guideline pooled it, 153 citations in OpenAlex.
- Consistent neurodegeneration and its association with clinical progression in Huntington's disease: a coordinate-based meta-analysis.Neuro-degenerative diseases · 2013Pooled it
- Neural and biomarker correlates of the Parkinson's Disease-Cognitive Rating Scale in Huntington's disease.Neuroimage. Reports · 2026Article
- Cerebrospinal Fluid Proenkephalin Predicts Striatal Atrophy Decades before Clinical Motor Diagnosis in Huntington's Disease.Movement disorders : official journal of the Movement Disorder Society · 2026Article
- Diffusion along Perivascular Spaces as a Marker for Glymphatic System Impairment in Huntington's Disease.Movement disorders : official journal of the Movement Disorder Society · 2025Article
- Autonomic dysfunction in neurodegenerative disease.Nature reviews. Neuroscience · 2025Review
- Genomic characterization of Huntington's disease genetic modifiers informs drug target tractability.Brain communications · 2025Article
- Cognitive reserve involves decision making and is associated with left parietal and hippocampal hypertrophy in neurodegeneration.Communications biology · 2024Article
- Rapid and high-purity differentiation of human medium spiny neurons reveals LMNB1 hypofunction and subtype necessity in modeling Huntington's disease.Inflammation and regeneration · 2024Article
- Comprehensive shape analysis of the cortex in Huntington's disease.Human brain mapping · 2023Article
- Brain, cognitive, and physical disability correlates of decreased quality of life in patients with Huntington's disease.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2023Article
- Longitudinal imaging highlights preferential basal ganglia circuit atrophy in Huntington's disease.Brain communications · 2023Article
- Benefits of global mutant huntingtin lowering diminish over time in a Huntington's disease mouse model.JCI insight · 2022Article
- Mutation-related magnetization-transfer, not axon density, drives white matter differences in premanifest Huntington disease: Evidence from in vivo ultra-strong gradient MRI.Human brain mapping · 2022Article
- Differential tractography as a dynamic imaging biomarker: A methodological pilot study for Huntington's disease.NeuroImage. Clinical · 2022Article
- Neurocognitive Features of Motor Premanifest Individuals With Myotonic Dystrophy Type 1.Neurology. Genetics · 2021Article
- Subcortical T1-Rho MRI Abnormalities in Juvenile-Onset Huntington's Disease.Brain sciences · 2020Article
- Utility of the Parkinson's disease-Cognitive Rating Scale for the screening of global cognitive status in Huntington's disease.Journal of neurology · 2020Article
- Robust Markers and Sample Sizes for Multicenter Trials of Huntington Disease.Annals of neurology · 2020Article
- Structural brain correlates of dementia in Huntington's disease.NeuroImage. Clinical · 2020Article
- SeSBAT: Single Subject Brain Analysis Toolbox. Application to Huntington's Disease as a Preliminary Study.Frontiers in systems neuroscience · 2020Article
5 more citing papers are in PubMed but not listed here.
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
Abstract
Neuroimaging studies of subjects who are gene-expanded for Huntington Disease, but not yet diagnosed (termed prodromal HD), report that the cortex is "spared," despite the decrement in striatal and cerebral white-matter volume. Measurement of whole-cortex volume can mask more subtle, but potentially clinically relevant regional changes in volume, thinning, or surface area. The current study addressed this limitation by evaluating cortical morphology of 523 prodromal HD subjects. Participants included 693 individuals enrolled in the PREDICT-HD protocol. Of these participants, 523 carried the HD gene mutation (prodromal HD group); the remaining 170 were non gene-expanded and served as the comparison group. Based on age and CAG repeat length, gene-expanded subjects were categorized as "Far from onset," "Midway to onset," "Near onset," and "already diagnosed." MRI scans were processed using FreeSurfer. Cortical volume, thickness, and surface area were not significantly different between the Far from onset group and controls. However, beginning in the Midway to onset group, the cortex showed significant volume decrement, affecting most the posterior and superior cerebral regions. This pattern progressed when evaluating the groups further into the disease process. Areas that remained mostly unaffected included ventral and medial regions of the frontal and temporal cortex. Morphologic changes were mostly in thinning as surface area did not substantially change in most regions. Early in the course of HD, the cortex shows changes that are manifest as cortical thinning and are most robust in the posterior and superior regions of the cerebrum.
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