ArticleInsect biochemistry and molecular biology2010
Leureptin: a soluble, extracellular leucine-rich repeat protein from Manduca sexta that binds lipopolysaccharide.
Article in Insect biochemistry and molecular biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 49 citations in OpenAlex.
- Insect immunity unveiled: exploring the molecular and cellular defenses against microbial threats.Archives of microbiology · 2026Review
- The Anopheles leucine-rich repeat protein APL1C is a pathogen binding factor recognizing Plasmodium ookinetes and sporozoites.PLoS pathogens · 2024Article
- LvCD14L Acts as a Novel Pattern Recognition Receptor and a Regulator of the Toll Signaling Pathway in Shrimp.International journal of molecular sciences · 2023Article
- Comparative transcriptome analysis of the newly discovered insect vector of the pine wood nematode in China, revealing putative genes related to host plant adaptation.BMC genomics · 2021Article
- Novel Characteristics of Immune Responsive Protein IRP30 in the Bumble Bee Bombus lantschouensis (Hymenoptera: Apidae).Journal of insect science (Online) · 2020Article
- Identification and Characterization of C-type Lectins in Ostrinia furnacalis (Lepidoptera: Pyralidae).Journal of insect science (Online) · 2018Article
- Annotation of the Asian Citrus Psyllid Genome Reveals a Reduced Innate Immune System.Frontiers in physiology · 2016Article
- Phylogenetic analysis and expression profiling of the pattern recognition receptors: Insights into molecular recognition of invading pathogens in Manduca sexta.Insect biochemistry and molecular biology · 2015Article
- Immunity-related genes in Ixodes scapularis--perspectives from genome information.Frontiers in cellular and infection microbiology · 2014Review
- A comprehensive analysis of the Manduca sexta immunotranscriptome.Developmental and comparative immunology · 2013Article
- RNA-Seq Study of Microbially Induced Hemocyte Transcripts from Larval Heliothis virescens (Lepidoptera: Noctuidae).Insects · 2012Article
- Pyrosequencing-based expression profiling and identification of differentially regulated genes from Manduca sexta, a lepidopteran model insect.Insect biochemistry and molecular biology · 2011Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Leucine-rich repeat containing proteins are involved in immune response in many capacities. In insects, these include Toll-like receptors and the Anopheles gambiae proteins APL1 and LRIM1. Here we describe the identification and characterization of leureptin, a novel extracellular protein with 13 leucine-rich repeats from hemolymph of the insect Manduca sexta. After injection of bacteria, leureptin mRNA level increased in fat body, but protein levels in plasma decreased, an indication that leureptin is consumed during the immune response. Leureptin bound to bacterial lipopolysaccharide (LPS). Microscopy using leureptin antiserum showed that leureptin associates with hemocytes after injection of bacteria, an indication that leureptin is involved in hemocyte responses to bacterial infection. Sequence database searches suggest similar proteins are present in other Lepidopteran species.
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