ArticleTissue engineering. Part C, Methods2011
Modeling tissue growth within nonwoven scaffolds pores.
Article in Tissue engineering. Part C, Methods, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- 3D Printed Mesh Geometry Modulates Immune Response and Interface Biology in Mouse and Sheep Model: Implications for Pelvic Floor Surgery.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Microarchitected Compliant Scaffolds of Pyrolytic Carbon for 3D Muscle Cell Growth.Advanced healthcare materials · 2024Article
- Emerging Nano/Micro-Structured Degradable Polymeric Meshes for Pelvic Floor Reconstruction.Nanomaterials (Basel, Switzerland) · 2020Review
- Tunable drug-loading capability of chitosan hydrogels with varied network architectures.Acta biomaterialia · 2014Article
- Article
- Technique for internal channelling of hydroentangled nonwoven scaffolds to enhance cell penetration.Journal of biomaterials applications · 2013Article
- Geometry-driven cell organization determines tissue growths in scaffold pores: consequences for fibronectin organization.PloS one · 2013Article
- Design and fabrication of tubular scaffolds via direct writing in a melt electrospinning mode.Biointerphases · 2012Article
- Comparative stability studies of poly(2-methyl-2-oxazoline) and poly(ethylene glycol) brush coatings.Biointerphases · 2012Article
Corrections and comments
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Authors and funding
7 authors.
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Abstract
In this study we present a novel approach for predicting tissue growth within the pores of fibrous tissue engineering scaffolds. Thin nonwoven polyethylene terephthalate scaffolds were prepared to characterize tissue growth within scaffold pores, by mouse NR6 fibroblast cells. On the basis of measurements of tissue lengths at fiber crossovers and along fiber segments, mathematical models were determined during the proliferative phase of cell growth. Tissue growth at fiber crossovers decreased with increasing interfiber angle, with exponential relationships determined on day 6 and 10 of culture. Analysis of tissue growth along fiber segments determined two growth profiles, one with enhanced growth as a result of increased tissue lengths near the fiber crossover, achieved in the latter stage of culture. Derived mathematical models were used in the development of a software program to visualize predicted tissue growth within a pore. This study identifies key pore parameters that contribute toward tissue growth, and suggests models for predicting this growth, based on fibroblast cells. Such models may be used in aiding scaffold design, for optimum pore infiltration during the tissue engineering process.
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