ArticleThe Journal of chemical physics2010
Polymer translocation through alpha-hemolysin pore with tunable polymer-pore electrostatic interaction.
Article in The Journal of chemical physics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
37 citing papers in PubMed.
- Bioinformatic and computational biophysics tools for nanopore engineering: a review from standard approaches to machine learning advancements.Journal of nanobiotechnology · 2026Review
- Complex and Non-sequential Current Signatures of a β-Hairpin Peptide Confined in a Nanopore.Analytical chemistry · 2025Article
- Unlocking the Power of Nanopores: Recent Advances in Biosensing Applications and Analog Front-End.Biosensors · 2023Review
- Translocation of Hydrophobic Polyelectrolytes under Electrical Field: Molecular Dynamics Study.Polymers · 2023Article
- Polymer Translocation and Nanopore Sequencing: A Review of Advances and Challenges.International journal of molecular sciences · 2023Review
- Driven translocation of a semiflexible polymer through a conical channel in the presence of attractive surface interactions.Scientific reports · 2022Article
- Quantification of Protein Glycosylation Using Nanopores.Nano letters · 2022Article
- Translocation, Rejection and Trapping of Polyampholytes.Polymers · 2022Article
- Enhanced Optical Spectroscopy for Multiplexed DNA and Protein-Sequencing with Plasmonic Nanopores: Challenges and Prospects.Analytical chemistry · 2022Article
- The Nanopore-Tweezing-Based, Targeted Detection of Nucleobases on Short Functionalized Peptide Nucleic Acid Sequences.Polymers · 2021Article
- Electroosmosis Dominates Electrophoresis of Antibiotic Transport Across the Outer Membrane Porin F.Biophysical journal · 2020Article
- Conformational fluctuations of a DNA electrophoretically translocating through a nanopore under the action of a motor protein.The European physical journal. E, Soft matter · 2019Article
- Theoretical Modeling of Polymer Translocation: From the Electrohydrodynamics of Short Polymers to the Fluctuating Long Polymers.Polymers · 2019Review
- Article
- Comparative biosensing of glycosaminoglycan hyaluronic acid oligo- and polysaccharides using aerolysin andThe European physical journal. E, Soft matter · 2018Article
- If Squeezed, a Camel Passes Through the Eye of a Needle: Voltage-Mediated Stretching of Dendrimers Facilitates Passage Through a Nanopore.The Journal of membrane biology · 2018Article
- Role of non-equilibrium conformations on driven polymer translocation.The Journal of chemical physics · 2018Article
- Porphyrin-Assisted Docking of a Thermophage Portal Protein into Lipid Bilayers: Nanopore Engineering and Characterization.ACS nano · 2017Article
- Nanoscale Investigation of Generation 1 PAMAM Dendrimers Interaction with a Protein Nanopore.Scientific reports · 2017Article
- Electrostatic Control of Polymer Translocation Speed throughMacromolecules · 2016Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
We have measured the ionic current blockages produced by single molecules of sodium poly(styrene sulfonate) passing through an alpha-hemolysin protein pore under an electric field. Most of the blockage events were composed of one or two blockage levels of ionic current. By analyzing the statistics of different event types for different polymer lengths, applied voltages, and pH conditions, we have identified the molecular mechanism behind the two-level blockages. Our analysis of the data shows that not all blockages are successful translocation events and the propensity of successful translocation can be tuned by pH gradients across the protein pore. We interpret our results as the change in protein-polymer interaction via protonation of charged amino acid residues of alpha-hemolysin pore. In addition, we have constructed a stochastic theory for polymer translocation through alpha-hemolysin pore with tunable polymer-pore interactions. The theoretical calculations capture many features observed in our experiments.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.