ArticleMolecular ecology2010
Xmrks the spot: life history tradeoffs, sexual selection and the evolutionary ecology of oncogenesis.
Article in Molecular ecology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed.
- Evolution ofInternational journal of molecular sciences · 2026Review
- Evolution of the MUC1 gene in eutherian mammals as an adaptation responsible for the increasing incidence of cancer in humans.Biochimica et biophysica acta. Reviews on cancer · 2026Review
- The Mystery of Cancer Resistance: A Revelation Within Nature.Journal of molecular evolution · 2023Review
- Review
- How Genes Modulate Patterns of Aging-Related Changes on the Way to 100: Biodemographic Models and Methods in Genetic Analyses of Longitudinal Data.North American actuarial journal : NAAJ · 2016Article
- Cancer susceptibility and reproductive trade-offs: a model of the evolution of cancer defences.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2015Article
- Trade-offs in the effects of the apolipoprotein E polymorphism on risks of diseases of the heart, cancer, and neurodegenerative disorders: insights on mechanisms from the Long Life Family Study.Rejuvenation research · 2015Article
- Unraveling genetic origin of aging-related traits: evolving concepts.Rejuvenation research · 2013Review
- Biogenetic mechanisms predisposing to complex phenotypes in parents may function differently in their children.The journals of gerontology. Series A, Biological sciences and medical sciences · 2013Article
- Genomics of human health and aging.Age (Dordrecht, Netherlands) · 2013Article
- Trade-off in the effect of the APOE gene on the ages at onset of cardiocascular disease and cancer across ages, gender, and human generations.Rejuvenation research · 2013Article
- Applying ecological and evolutionary theory to cancer: a long and winding road.Evolutionary applications · 2013Article
Corrections and comments
- Comment on
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In a classic paper, George Williams (1957) argued that alleles promoting reproductive success early in life may be favoured by selection, even if they reduce the lifespan of individuals that bear the allele. A variety of evidence supports the theory that such 'antagonistic pleiotropy' is a major factor contributing to the evolution of senescence (Ljubuncic & Reznick 2009), but examples of specific alleles known to fulfil Williams' criteria remain rare, in both humans and other animals (e.g. Alexander et al. 2007; Kulminski et al. 2010). An intriguing example in this issue of Molecular Ecology (Fernandez & Bowser 2010) demonstrates that both natural and sexual selection may favour melanoma-promoting oncogene alleles in the fish genus Xiphophorus.
Indexed as
Identifiers
20687246What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.