Evidence map›Paper›PMID 20687086›Full record

SynthesisThe Cochrane database of systematic reviews2010

Alternative magnesium sulphate regimens for women with pre-eclampsia and eclampsia.

Lelia Duley, Hosam E Matar, Muhammad Qutayba Almerie, David R Hall

Open access · greenAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in The Cochrane database of systematic reviews, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 10 pooled it
5.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 10 syntheses or guidelines pooled it, 90 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Magnesium sulphate versus diazepam for eclampsia.The Cochrane database of systematic reviews · 2010
    Pooled it
  8. Magnesium sulphate and other anticonvulsants for women with pre-eclampsia.The Cochrane database of systematic reviews · 2010
    Pooled it
  9. Magnesium sulphate versus phenytoin for eclampsia.The Cochrane database of systematic reviews · 2010
    Pooled it
  10. Magnesium sulphate versus lytic cocktail for eclampsia.The Cochrane database of systematic reviews · 2010
    Pooled it
  11. Trial
  12. Trial
  13. Review
  14. Review
  15. Management and Prevention of Pre-Eclampsia in Nigeria.Healthcare (Basel, Switzerland) · 2023
    Article
  16. Article
  17. Review
  18. Article
  19. Hypertensive disorders in pregnancy.Indian journal of anaesthesia · 2018
    Review
  20. Adverse drug reactions in high-risk pregnant women: A prospective study.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2017
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

Lelia DuleyCentre for Epidemiology and Biostatistics, University of Leeds, Bradford Institute for Health Research, Bradford Royal Infirmary, Duckworth Lane, Bradford, West Yorkshire, UK, BD9 6RJ.
Hosam E Matar
Muhammad Qutayba Almerie
David R Hall
Middlesex University · GBStellenbosch University · ZAUniversity of Nottingham · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMagnesium sulphate remains the drug of choice for both prevention and treatment of women with eclampsia. Regimens for administration of this drug have evolved over the years, but have not yet been formally evaluated.

objectivesTo assess the comparative effects of alternative regimens for the administration of magnesium sulphate when used for the care of women with pre-eclampsia or eclampsia, or both. SEARCH STRATEGY: We searched the Cochrane Pregnancy and Childbirth Group's Trials Register (June 2010). SELECTION CRITERIA: Randomised trials comparing different regimens for administration of magnesium sulphate used for the care of women with pre-eclampsia or eclampsia, or both. DATA COLLECTION AND ANALYSIS: All four review authors assessed trial quality and extracted data independently. MAIN

resultsWe identified 17 studies of which six (866 women) met the inclusion criteria: two trials (451 women) compared regimens for women with eclampsia and four (415 women) for women with pre-eclampsia.Treatment of eclampsia: one trial compared loading dose alone with loading dose plus maintenance therapy for 24 hours (401 women). There was no clear difference between the groups in the risk ratio (RR) of recurrence of convulsions (RR 1.13, 95% confidence interval (CI) 0.42 to 3.05) or stillbirth (RR 1.13, 95% CI 0.66 to 1.92), and the CIs are wide. One trial compared a low dose regimen with a standard dose regimen over 24 hours (50 women). This study was too small for any reliable conclusions about the comparative effects.Prevention of eclampsia: one trial compared intravenous with intramuscular maintenance regimen for 24 hours (17 women). This trial was too small for any reliable conclusions. Three trials compared short maintenance regimens postpartum with continuing for 24 hours after the birth (398 women), even taken together these trials were too small for any reliable conclusions. AUTHORS'

conclusionsAlthough strong evidence supports the use of magnesium sulphate for prevention and treatment of eclampsia, trials comparing alternative treatment regimens are too small for reliable conclusions.

Indexed as

AnticonvulsantsCalcium Channel BlockersEclampsiaFemaleHumansMagnesium SulfatePre-EclampsiaPregnancyRandomized Controlled Trials as TopicAnticonvulsantsCalcium Channel BlockersMagnesium Sulfate

Identifiers

PMID20687086
PMCPMC8935538
OpenAlexW2099169141

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.