ArticleJournal of gastroenterology2011
A Japanese case series of 12 patients with esophageal eosinophilia.
Article in Journal of gastroenterology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 4 of them syntheses that pooled it.
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Who cites it
32 citing papers in PubMed, 4 syntheses or guidelines pooled it, 71 citations in OpenAlex.
- Technical Review on the Management of Eosinophilic Esophagitis: A Report From the AGA Institute and the Joint Task Force on Allergy-Immunology Practice Parameters.Gastroenterology · 2020Guideline
- Six-Food Elimination Diet and Topical Steroids are Effective for Eosinophilic Esophagitis: A Meta-Regression.Digestive diseases and sciences · 2017Pooled it
- Guideline
- Systematic review: Eosinophilic esophagitis in Asian countries.World journal of gastroenterology · 2015Pooled it
- Article
- Prevalence of Eosinophilic Esophagitis in Patients With Gastroesophageal Reflux Symptoms.Cureus · 2025Article
- Mucosal color changes on narrow-band imaging in esophageal eosinophilic infiltration.Medicine · 2022Article
- Proton Pump Inhibitor Therapy for Eosinophilic Esophagitis: History, Mechanisms, Efficacy, and Future Directions.Journal of asthma and allergy · 2022Review
- How to approach adult patients with asymptomatic esophageal eosinophilia.Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus · 2021Review
- Clinical Features of Esophageal Eosinophilia According to Endoscopic Phenotypes.Internal medicine (Tokyo, Japan) · 2020Article
- Symptom-based diagnostic approach for eosinophilic esophagitis.Journal of gastroenterology · 2020Review
- Technical review on the management of eosinophilic esophagitis: a report from the AGA institute and the joint task force on allergy-immunology practice parameters.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2020Review
- A Single-center Experience of Esophageal Eosinophilia.The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi · 2018Article
- Trend, clinical presentations and diagnosis of eosinophilic esophagitis in Saudi children.Saudi medical journal · 2018Article
- A Prospective Study of Eosinophilic Esophagitis and the Expression of Tight Junction Proteins in Patients with Gastroesophageal Reflux Disease Symptoms.Gut and liver · 2018Article
- Diagnosis and treatment of eosinophilic esophagitis in clinical practice.Clinical journal of gastroenterology · 2017Review
- Similarities and differences among eosinophilic esophagitis, proton-pump inhibitor-responsive esophageal eosinophilia, and reflux esophagitis: comparisons of clinical, endoscopic, and histopathological findings in Japanese patients.Journal of gastroenterology · 2017Article
- Clinicopathologic Analysis of Proton Pump Inhibitor-Responsive Esophageal Eosinophilia in Korean Patients.Gut and liver · 2016Article
- The changing faces of eosinophilic esophagitis: the impact of consensus guidelines at the University of South Florida.Digestive diseases and sciences · 2015Article
- Eosinophilic esophagitis and proton pump inhibitors: controversies and implications for clinical practice.Gastroenterology & hepatology · 2014Article
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEosinophilic esophagitis (EoE) has been a rarely recognized condition in Asian populations, and its clinical manifestation is rarely documented. Our aim was to describe clinically, endoscopically, and pathologically the features of patients with esophageal eosinophilia, including EoE.
methodsTwelve patients histologically proven to have esophageal eosinophilia were investigated. The histological diagnostic cutoff value was defined as a peak of ≥15 eosinophils/high-power field (HPF) in esophageal biopsies. Symptoms, endoscopic and pathological findings, and treatment outcome were evaluated.
resultsNine of the 12 patients were male and the 12 patients had a mean age of 47.7 years. Allergic conditions were concurrent in a total of 3 patients. Mild peripheral eosinophilia was observed in only 2 patients. The predominant symptom was solid-food dysphagia, but some patients complained of heartburn, or chest, epigastric, or back pain. Three asymptomatic subjects were also incidentally diagnosed during endoscopic screening. Linear furrows, concentric rings, and white exudates in the esophagus were frequently observed. In 4 of 5 patients who were administered a proton pump inhibitor (PPI), esophageal eosinophilia was histologically decreased or disappeared with symptom relief and endoscopic improvement. In 2 patients unresponsive to PPI, topical steroid therapy, administered by the swallowing of fluticasone propionate, led to symptomatic and histological remission.
conclusionsThe endoscopic recognition of linear furrows, concentric rings, and white exudates is important in the diagnosis of eosinophilic esophageal inflammation. In a subset of patients this condition improves clinicopathologically with PPI treatment, and typical EoE, as strictly defined by unresponsiveness to PPI, appears to be a rather rare condition.
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