ArticleMolecular imaging and biology2011
Functional phenotyping of the maternal albumin turnover in the mouse placenta by dynamic contrast-enhanced MRI.
Article in Molecular imaging and biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Novel multimodal molecular imaging of Vitamin H (Biotin) transporter activity in the murine placenta.Scientific reports · 2020Article
- Galectin-3 deficiency in pregnancy increases the risk of fetal growth restriction (FGR) via placental insufficiency.Cell death & disease · 2020Article
- Molecular pathways of senescence regulate placental structure and function.The EMBO journal · 2019Article
- Perspectives: MRI of angiogenesis.Journal of magnetic resonance (San Diego, Calif. : 1997) · 2018Review
- Multifunctional nanoparticles for real-time evaluation of toxicity during fetal development.PloS one · 2018Article
- Functional MRI of the placenta--From rodents to humans.Placenta · 2015Review
- Major mouse placental compartments revealed by diffusion-weighted MRI, contrast-enhanced MRI, and fluorescence imaging.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Magnetic resonance imaging detects placental hypoxia and acidosis in mouse models of perturbed pregnancies.PloS one · 2013Article
- Regulation of pregnancy maintenance and fetal survival in mice by CD27(low) mature NK cells.Journal of molecular medicine (Berlin, Germany) · 2012Article
- The hemodynamic basis for positional- and inter-fetal dependent effects in dual arterial supply of mouse pregnancies.PloS one · 2012Article
- A role for Notch signaling in trophoblast endovascular invasion and in the pathogenesis of pre-eclampsia.Development (Cambridge, England) · 2011Article
- Survival and size are differentially regulated by placental and fetal PKBalpha/AKT1 in mice.Biology of reproduction · 2011Article
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Authors and funding
7 authors.
Funding
Abstract
purposeThe purpose of this study was to develop a tool for functional phenotyping of the maternal circulation in the mouse placenta. PROCEDURES: In utero macromolecular dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) was performed on embryonic day 10.5 (E10.5), E13.5, and E18.5. Fluorescence analysis was also used for validation of the results.
resultsThe initial rate of contrast enhancement revealed an increased maternal blood volume fraction as the pregnancy progressed. Serial imaging of E10.5 and E13.5 placentas revealed a loss of contrast enhancement due to phagocytic uptake. A key application of macromolecular DCE-MRI would be to follow mouse pregnancies during fetal and placental manipulation including embryo transfer, tetraploid complementation, and fetal resorptions. We were able to resolve strain differences in ICR outbred mice carrying both ICR and C57Bl/6J embryos and to differentiate in utero resorptions from functional placentas.
conclusionsOur results highlight the importance of the functional in utero analysis of placental vascularization in physiological phenotyping of transgenic mice and suggest MRI, particularly macromolecular DCE-MRI, as a non-invasive tool for the analysis of the placenta.
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