ArticleMolecular imaging and biology2011
The use of cellular magnetic resonance imaging to track the fate of iron-labeled multipotent stromal cells after direct transplantation in a mouse model of spinal cord injury.
Article in Molecular imaging and biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 43 citations in OpenAlex.
- Whole-Body Imaging to Assess Cell-Based Immunotherapy: Preclinical Studies with an Update on Clinical Translation.Molecular imaging and biology · 2022Review
- Review
- A Perspective on Cell Tracking with Magnetic Particle Imaging.Tomography (Ann Arbor, Mich.) · 2020Article
- Mesenchymal stem cell therapy for liver disease: full of chances and challenges.Cell & bioscience · 2020Review
- Ferumoxytol Labeling of Human Neural Progenitor Cells for Diagnostic Cellular Tracking in the Porcine Spinal Cord with Magnetic Resonance Imaging.Stem cells translational medicine · 2017Article
- Stem Cells and Labeling for Spinal Cord Injury.International journal of molecular sciences · 2016Review
- A multimodality imaging model to track viable breast cancer cells from single arrest to metastasis in the mouse brain.Scientific reports · 2016Article
- Current Concept of Stem Cell Therapy for Spinal Cord Injury: A Review.Korean journal of neurotrauma · 2016Review
- MRI-Based Assessment of Intralesional Delivery of Bone Marrow-Derived Mesenchymal Stem Cells in a Model of Equine Tendonitis.Stem cells international · 2016Article
- Imaging transplanted stem cells in real time using an MRI dual-contrast method.Scientific reports · 2015Article
- Article
- Neural stem cell transplantation in experimental contusive model of spinal cord injury.Journal of visualized experiments : JoVE · 2014Article
- Imaging tumor growth non-invasively using expression of MagA or modified ferritin subunits to augment intracellular contrast for repetitive MRI.Molecular imaging and biology · 2014Article
- Brain metastases from breast cancer: lessons from experimental magnetic resonance imaging studies and clinical implications.Journal of molecular medicine (Berlin, Germany) · 2014Review
- In vivo MR detection of fluorine-labeled human MSC using the bSSFP sequence.International journal of nanomedicine · 2014Article
- MRI detection of nonproliferative tumor cells in lymph node metastases using iron oxide particles in a mouse model of breast cancer.Translational oncology · 2013Article
- Extensive expansion of primary human gamma delta T cells generates cytotoxic effector memory cells that can be labeled with Feraheme for cellular MRI.Cancer immunology, immunotherapy : CII · 2013Article
- Specific chemotaxis of magnetically labeled mesenchymal stem cells: implications for MRI of glioma.Molecular imaging and biology · 2012Article
- In vivo MRI discrimination between live and lysed iron-labelled cells using balanced steady state free precession.European radiology · 2012Article
- Stem cell therapy for the spinal cord.Stem cell research & therapy · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
Abstract
purposeThe objective of this study was to track the fate of iron-labeled, multipotent stromal cells (MSC) after their direct transplantation into mice with spinal cord injuries using magnetic resonance imaging (MRI). PROCEDURES: Mice with spinal cord injuries received a direct transplant of (1) live MSC labeled with micron-sized iron oxide particles (MPIO); (2) dead, MPIO-labeled MSC; (3) unlabeled MSC; or (4) free MPIO and were imaged at 3 T for 6 weeks after transplantation.
resultsLive, iron-labeled MSC appeared as a well-defined region of signal loss in the mouse spinal cord at the site of transplant. However, the MR appearance of dead, iron-labeled MSC and free iron particles was similar and persisted for the 6 weeks of the study.
conclusionsIron-labeled stem cells can be detected and monitored in vivo after direct transplantation into the injured spinal cord of mice. However, the fate of the iron label is not clear. Our investigation indicates that caution should be taken when interpreting MR images after direct transplantation of iron-labeled cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.