ArticleJournal of neuro-oncology2011
Growth curve analysis of asymptomatic and symptomatic meningiomas.
Article in Journal of neuro-oncology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 2 of them syntheses that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Natural History of Meningiomas: Review with Meta-analyses.Neurologia medico-chirurgica · 2020Pooled it
- Volumetric growth rates of meningioma and its correlation with histological diagnosis and clinical outcome: a systematic review.Acta neurochirurgica · 2017Pooled it
- A Case Report Depicting a Rare Neurosurgical Disease: Aggressive Meningiomatosis.Journal of clinical medicine · 2025Article
- Malignant Transformation of Meningiomas.Journal of Cancer · 2025Review
- Meningioma: International Consortium on Meningiomas consensus review on scientific advances and treatment paradigms for clinicians, researchers, and patients.Neuro-oncology · 2024Review
- Malignant Transformation of Meningioma WithBrain tumor research and treatment · 2024Article
- Growth dynamics of incidental meningiomas: A prospective long-term follow-up study.Neuro-oncology practice · 2023Article
- The management of incidental meningioma: An unresolved clinical conundrum.Neuro-oncology advances · 2023Article
- Physics-based tissue simulator to model multicellular systems: A study of liver regeneration and hepatocellular carcinoma recurrence.PLoS computational biology · 2023Article
- Clinical Presentation and Prognosis.Advances in experimental medicine and biology · 2023Article
- Tumor doubling time as preoperative predictor of malignancy and recurrence in newly diagnosed meningioma.Neurosurgical review · 2022Article
- Article
- Liquid biopsies for early diagnosis of brain tumours:Journal of the Royal Society, Interface · 2022Article
- Characterization of pediatric brain tumors using pre-diagnostic neuroimaging.Frontiers in oncology · 2022Article
- The growth rate and clinical outcomes of radiation induced meningioma undergoing treatment or active monitoring.Journal of neuro-oncology · 2021Article
- Article
- A prospective study of the natural history of incidental meningioma-Hold your horses!Neuro-oncology practice · 2019Article
- Theragnostic Use of Radiolabelled Dota-Peptides in Meningioma: From Clinical Demand to Future Applications.Cancers · 2019Review
- CT Hounsfield Unit Is a Good Predictor of Growth in Meningiomas.Neurologia medico-chirurgica · 2019Article
- Mathematical Models for Tumor Growth and the Reduction of Overtreatment.Journal of neurological surgery. Part B, Skull base · 2019Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Meningiomas sometimes appear to stop growing after attaining a large size. Commonly used exponential growth models do not reflect this phenomenon. We attempted to find the best curve to simulate their growth. Fifty-two patients with meningioma were followed up for 3.1-21.7 years (mean 7.5 years) with four or more imaging studies each. Thirty-one patients had asymptomatic tumors. The other 21 patients with residual or recurrent tumor were followed up after surgery. Time-volume curves for each tumor were plotted. Nonlinear regression analyses were performed against power, exponential, logistic, and Gompertzian curves. Time-volume curves corresponded to the Gompertzian and logistic growth curves better than to power or exponential curves. When simulating time-volume curves with Gompertzian curves, the majority of benign meningiomas began to slow their growth before patient age of 80 years. Twenty-three of 31 asymptomatic meningiomas had already passed the inflection point before diagnosis. In contrast, this happened less frequently in symptomatic tumors. Especially, all six atypical meningiomas continued to grow quasi-exponentially. Sigmoid curves that approach a plateau were better descriptors of the growth of benign meningiomas than were curves of unlimited growth. However, atypical meningiomas were unlikely to slow their growth.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.