ReviewInternational journal of colorectal disease2011
Signet-ring cell carcinoma of colorectum--current perspectives and molecular biology.
Review in International journal of colorectal disease, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 1 of them a synthesis that pooled it.
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Who cites it
47 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.
- The Molecular Associations of Signet-Ring Cell Carcinoma in Colorectum: Meta-Analysis and System Review.Medicina (Kaunas, Lithuania) · 2022Pooled it
- Signet ring cell colorectal cancer: genomic insights into a rare subpopulation of colorectal adenocarcinoma.British journal of cancer · 2019Trial
- Signet-Ring Cell Colorectal Cancer and Signet-Ring Cell Component Colorectal Cancer: Do They Differ in Clinical Behavior?Journal of clinical medicine · 2026Article
- A predictive and prognostic model for metastasis risk and prognostic factors in gastrointestinal signet ring cell carcinoma.European journal of medical research · 2024Article
- Calcified Primary Signet Ring Cell Carcinoma of the Colon with Metastases.Radiology. Imaging cancer · 2024Article
- A novel log odds of positive lymph nodes-based nomogram for predicting overall survival in patients with colorectal signet ring cell carcinoma: a SEER population-based study.International journal of colorectal disease · 2024Article
- The prognostic ability of radiotherapy of different colorectal cancer histological subtypes and tumor sites.Scientific reports · 2023Article
- Molecular genetic and clinical characteristic analysis of primary signet ring cell carcinoma of urinary bladder identified by a novel OR2L5 mutation.Cancer medicine · 2023Article
- Comparative analysis of tumor biology and prognosis in mucinous and signet-ring cell colon cancersFrontiers in physiology · 2023Article
- Clinical features and prognostic factors of esophageal signet ring cell carcinoma: construction and validation of a model based on the SEER database.Translational cancer research · 2022Article
- Article
- Predictors of Long-Time Survivors in Nonmetastatic Colorectal Signet Ring Cell Carcinoma: A Large Population-Based Study.Gastroenterology research and practice · 2022Article
- Impact of histological subtype on prognosis in stage IV colorectal cancer: A population-based cohort study.PloS one · 2022Article
- MRI features of signet ring rectal cancer.Abdominal radiology (New York) · 2021Article
- Trends in the Incidence and Survival Rates of Colorectal Signet-Ring Cell Carcinoma in the South Korean Population: Analysis of the Korea Central Cancer Registry Database.Journal of clinical medicine · 2021Article
- Colorectal cancer under 20 years old: a retrospective analysis from three tertiary hospitals.Journal of cancer research and clinical oncology · 2021Article
- Clinicopathological and Molecular Characteristics of Colorectal Signet Ring Cell Carcinoma: A Review.Pathology oncology research : POR · 2021Review
- Clinicopathological characteristics and survival in colorectal signet ring cell carcinoma: a population-based study.Scientific reports · 2020Article
- Primary signet ring cell carcinoma with tubular adenoma of the rectum: A case report and a review of the literature.Medicine · 2020Review
- Mucinous rectal cancer: concepts and imaging challenges.Abdominal radiology (New York) · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeColorectal signet-ring cell carcinoma (SRCC) is rare, and very little detailed information on the molecular biology of the disease is available.
methodsThe literature on the clinical, pathological and, in particular, the molecular biology of this rare entity was critically reviewed. The reviewed articles take into account a total of 1,817 cases of SRCC, but only 143 cases have molecular data available. The characteristics of two patients with colorectal SRCC were also discussed.
resultsColorectal SRCC mostly occurs in younger patients, is larger and has different site predilection compared with conventional colorectal adenocarcinoma. It can occur as one of the synchronous cancers in the colorectum. The cancer is usually diagnosed at advanced stages because of the late manifestation of symptoms, and aggressive treatment strategy is required. Limited reports in the literature have shown that the variant of colorectal cancer demonstrated a different pattern of genetic alterations of common growth kinase-related oncogenes (K-ras, BRAF), tumour suppressor genes (p53, p16), gene methylation and cell adhesion-related genes related to the Wingless signalling pathway (E-cadherin and beta-catenin) from conventional colorectal adenocarcinoma. Colorectal SRCC also showed high expression of mucin-related genes and genes related to the gastrointestinal system. There was also a higher prevalence of microsatellite instability-high tumours and low Cox-2 expression in colorectal SRCC as opposed to conventional adenocarcinoma.
conclusionsColorectal SRCC has unique molecular pathological features. The unique molecular profiles in SRCC may provide molecular-based improvements to patient management in colorectal SRCC.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.