ArticlePloS one2010
TOR is a negative regulator of autophagy in Arabidopsis thaliana.
Article in PloS one, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 140 papers.
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140 citing papers in PubMed, 265 citations in OpenAlex.
- A Regulatory Network of Transcription and Hormones Controls PCD and Autophagy in Grape Seed Abortion.International journal of molecular sciences · 2026Article
- Chloroplast Protein Degradation Pathways During Leaf Senescence: Coordination and Roles in Nitrogen Remobilization.Plants (Basel, Switzerland) · 2026Review
- Amino Acids as Multifunctional Molecules in Plants: From Fundamental Metabolism to Precision Agriculture.Plants (Basel, Switzerland) · 2026Review
- Context-dependent coordination of TOR and SnRK1 signaling under carbon and nitrogen perturbations.Frontiers in plant science · 2026Article
- Review
- Peptide AEDL Activates Metabolism and Autophagy in Root Cells ofInternational journal of molecular sciences · 2025Article
- Changes in macromolecular content and AOX activity of Ustilago maydis: from exponential to stationary phase.Archives of microbiology · 2025Article
- RD21 enhances resistance to the strawberry vein banding virus by promoting autophagy-mediated degradation of the viral silencing suppressor P6 protein.Plant biotechnology journal · 2025Article
- Brassinosteroid Signaling Dynamics: Ubiquitination-Dependent Regulation of Core Signaling Components.International journal of molecular sciences · 2025Review
- Oiling the wheels of growth: TOR kinase promotes lipid synthesis in plants.Plant physiology · 2025Article
- The target of rapamycin kinase is a positive regulator of plant fatty acid and lipid synthesis.Plant physiology · 2025Article
- The critical roles of three sugar-related proteins (HXK, SnRK1, TOR) in regulating plant growth and stress responses.Horticulture research · 2024Article
- Sugar signals pedal the cell cycle!Frontiers in plant science · 2024Review
- Three consecutive cytosolic glycolysis enzymes modulate autophagic flux.Plant physiology · 2023Article
- Studying plant autophagy: challenges and recommended methodologies.Advanced biotechnology · 2023Review
- Transcriptional and post-translational regulation of plant autophagy.Journal of experimental botany · 2023Review
- Brassinosteroids modulate autophagy through phosphorylation of RAPTOR1B by the GSK3-like kinase BIN2 in Arabidopsis.Autophagy · 2023Article
- To Kill or to Be Killed: How Does the Battle between the UPS and Autophagy Maintain the Intracellular Homeostasis in Eukaryotes?International journal of molecular sciences · 2023Review
- Improving crop yield potential: Underlying biological processes and future prospects.Food and energy security · 2023Review
- Plant autophagosomes mature into amphisomes prior to their delivery to the central vacuole.The Journal of cell biology · 2022Article
80 more citing papers are in PubMed but not listed here.
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAutophagy is a protein degradation process by which cells recycle cytoplasmic contents under stress conditions or during senescence; a basal level of housekeeping autophagy also occurs under non-stressed conditions. Although a number of genes that function in autophagy (ATG genes) have been identified in plants, the upstream components that regulate the plant autophagy pathway are still obscure. Target of rapamycin (TOR) is a negative regulator of autophagy in both yeast and animals, and homologs of TOR in plants control plant growth and protein synthesis. However, a role for TOR in regulation of autophagy in plants has not been demonstrated previously. METHODOLOGY/PRINCIPAL
findingsIn this paper we used RNA interference (RNAi) to generate transgenic plants with reduced AtTOR transcript level. By observing monodansylcadaverine- (MDC) and GFP-AtATG8e-labeled autophagosomes, these plants were demonstrated to have constitutive AtATG18a-dependent autophagy. Reverse transcriptase-PCR also showed increased expression of some AtATG genes in the RNAi-AtTOR plants. Unlike autophagy induced by starvation or salt stress, an NADPH oxidase inhibitor did not inhibit the constitutive autophagy in the RNAi-AtTOR lines, indicating that AtTOR is either downstream of or in a parallel pathway to NADPH oxidase. CONCLUSIONS/SIGNIFICANCE: Together, our results provide evidence that TOR is a negative regulator of autophagy in plants.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.