ArticleNature2010
The Amphimedon queenslandica genome and the evolution of animal complexity.
Article in Nature, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 502 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
502 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Rethinking Plasticity in Sponges.Journal of experimental zoology. Part B, Molecular and developmental evolution · 2026Pooled it
- Topological mixing and irreversibility in animal chromosome evolution.Science advances · 2026Article
- Investigations of the Evolved Molecular Basis for Terpenoid Biosynthesis in Marine Sponges.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Rapid evolution of lncRNAs introduces novel regulatory inputs into ancestral cancer pathways.Science advances · 2026Article
- Reproduction and Development in Calcareous Sponges: A Panorama of the Last Two Centuries.Molecular reproduction and development · 2026Review
- Manzamine-A: Unraveling the Chemical and Biological Tapestry of a Marine-Derived Drug Lead.Marine drugs · 2026Review
- A sponge homolog of BRMS1 reveals ancient origin of metastasis-suppressing functions.BMC biology · 2026Article
- Cosmopolitan Gene Families With Known Functions Are Hotspots for the Evolution of Novel Genes in Stony Corals.Genome biology and evolution · 2026Article
- Review
- An in vitro cellular model for measuring the impact of thermal stress on Florida reef sponges.In vitro cellular & developmental biology. Animal · 2026Article
- Microbiome-mediated polyphosphate accumulation enhances the resilience of sponge holobionts to future climate scenarios.The ISME journal · 2026Article
- Early transcription factor activation distinguishes symbiotic from non-symbiotic bacteria during microbiome processing in a sponge.The ISME journal · 2026Article
- Understanding cancer as a systemic disease through comprehension of neural stemness as the core property of cancer cell and the basic rules it dictates.Frontiers in cell and developmental biology · 2026Review
- NOD-like receptor repertoire in the chromosome-level genome of the demospongeFrontiers in immunology · 2026Article
- The hidden Markov model and its applications in bioinformatics analysis.Genes & diseases · 2026Review
- First draft genome assembly of sponge Halisarca dujardinii reveals key components of basement membrane and broad repertoire of aggregation factors.Scientific reports · 2025Article
- G-protein-coupled receptor diversity and evolution in the closest living relatives of metazoa.eLife · 2025Article
- Article
- The evolutionary foundations of transcriptional regulation in animals.Nature reviews. Genetics · 2025Review
- Transcriptomic Insights Into the Immune Repertoire of an Antarctic Sponge.Ecology and evolution · 2025Article
442 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
33 authors.
Funding
Abstract
Sponges are an ancient group of animals that diverged from other metazoans over 600 million years ago. Here we present the draft genome sequence of Amphimedon queenslandica, a demosponge from the Great Barrier Reef, and show that it is remarkably similar to other animal genomes in content, structure and organization. Comparative analysis enabled by the sequencing of the sponge genome reveals genomic events linked to the origin and early evolution of animals, including the appearance, expansion and diversification of pan-metazoan transcription factor, signalling pathway and structural genes. This diverse 'toolkit' of genes correlates with critical aspects of all metazoan body plans, and comprises cell cycle control and growth, development, somatic- and germ-cell specification, cell adhesion, innate immunity and allorecognition. Notably, many of the genes associated with the emergence of animals are also implicated in cancer, which arises from defects in basic processes associated with metazoan multicellularity.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.