SynthesisNature2010
Biological, clinical and population relevance of 95 loci for blood lipids.
Open access · greenAbstract readMeta-Analysis
In one paragraph
Synthesis in Nature, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2,124 papers, 7 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
2,124citing papers in PubMed, 7 pooled it
173.4field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2,124 citing papers in PubMed, 7 syntheses or guidelines pooled it, 3,661 citations in OpenAlex.
- Context-Dependent Associations of theInternational journal of molecular sciences · 2026Pooled it
- Integrative genetic and liver transcriptomic analyses identify TRIB1AL as a target for steatotic liver disease.The Journal of clinical endocrinology and metabolism · 2026Pooled it
- Genome-wide gene-sleep interaction study identifies novel lipid loci in 732,564 participants.Atherosclerosis · 2026Pooled it
- Multi-ancestry genome-wide association analyses incorporating SNP-by-psychosocial interactions identify novel loci for serum lipids.Translational psychiatry · 2025Pooled it
- Large-scale multi-omics analyses in Hispanic/Latino populations identify genes for cardiometabolic traits.Nature communications · 2025Pooled it
- Multiomic integration analysis identifies atherogenic metabolites mediating between novel immune genes and cardiovascular risk.Genome medicine · 2024Pooled it
- Genetic insights into resting heart rate and its role in cardiovascular disease.Nature communications · 2023Pooled it
- Phospholipases: Where Do We Stand?Methods in molecular biology (Clifton, N.J.) · 2027Review
- Impact of Genetics on Endocrine Manifestations of Cystic Fibrosis.Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists · 2026Review
- Pleiotropy and eQTL analysis identify shared genetic architecture of lipid traits in African-ancestry populations.Human molecular genetics · 2026Article
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- Can Polygenic Risk Scores for Metabolic Syndrome Contribute to Long-Term Syndrome Development in First-Episode Psychosis Patients? A Naturalistic 21-Year Follow-Up Study.Schizophrenia bulletin · 2026Article
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- PCSK9 rs562556 variant and survival in BRCA1 mutation carriers and mutation-negative familial breast cancer.NPJ breast cancer · 2026Article
- Hepatic Lipoprotein Production, Cardiometabolic Phenotypes, and Subtypes of Steatotic Liver Disease.Circulation research · 2026Review
2,064 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
209 authors at 20 institutions in 17 countries.
Tanya M TeslovichCenter for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan 48109, USA.
Kiran Musunuru
Albert V Smith
Andrew C Edmondson
Ioannis M Stylianou
Masahiro Koseki
James P Pirruccello
Samuli Ripatti
Daniel I Chasman
Cristen J Willer
Christopher T Johansen
Sigrid W Fouchier
Aaron Isaacs
Gina M Peloso
Maja Barbalic
Sally L Ricketts
Joshua C Bis
Yurii S Aulchenko
Gudmar Thorleifsson
Mary F Feitosa
John Chambers
Marju Orho-Melander
Olle Melander
Toby Johnson
Xiaohui Li
Xiuqing Guo
Mingyao Li
Yoon Shin Cho
Min Jin Go
Young Jin Kim
Jong-Young Lee
Taesung Park
Kyunga Kim
Xueling Sim
Rick Twee-Hee Ong
Damien C Croteau-Chonka
Leslie A Lange
Joshua D Smith
Kijoung Song
Jing Hua Zhao
Xin Yuan
Jian'an Luan
Claudia Lamina
Andreas Ziegler
Weihua Zhang
Robert Y L Zee
Alan F Wright
Jacqueline C M Witteman
James F Wilson
Gonneke Willemsen
H-Erich Wichmann
John B Whitfield
Dawn M Waterworth
Nicholas J Wareham
Gérard Waeber
Peter Vollenweider
Benjamin F Voight
Veronique Vitart
Andre G Uitterlinden
Manuela Uda
Jaakko Tuomilehto
John R Thompson
Toshiko Tanaka
Ida Surakka
Heather M Stringham
Tim D Spector
Nicole Soranzo
Johannes H Smit
Juha Sinisalo
Kaisa Silander
Eric J G Sijbrands
Angelo Scuteri
James Scott
David Schlessinger
Serena Sanna
Veikko Salomaa
Juha Saharinen
Chiara Sabatti
Aimo Ruokonen
Igor Rudan
Lynda M Rose
Robert Roberts
Mark Rieder
Bruce M Psaty
Peter P Pramstaller
Irene Pichler
Markus Perola
Brenda W J H Penninx
Nancy L Pedersen
Cristian Pattaro
Alex N Parker
Guillaume Pare
Ben A Oostra
Christopher J O'Donnell
Markku S Nieminen
Deborah A Nickerson
Grant W Montgomery
Thomas Meitinger
Ruth McPherson
Mark I McCarthy
Wendy McArdle
David Masson
Nicholas G Martin
Fabio Marroni
Massimo Mangino
Patrik K E Magnusson
Gavin Lucas
Robert Luben
Ruth J F Loos
Marja-Liisa Lokki
Guillaume Lettre
Claudia Langenberg
Lenore J Launer
Edward G Lakatta
Reijo Laaksonen
Kirsten O Kyvik
Florian Kronenberg
Inke R König
Kay-Tee Khaw
Jaakko Kaprio
Lee M Kaplan
Asa Johansson
Marjo-Riitta Jarvelin
A Cecile J W Janssens
Erik Ingelsson
Wilmar Igl
G Kees Hovingh
Jouke-Jan Hottenga
Albert Hofman
Andrew A Hicks
Christian Hengstenberg
Iris M Heid
Caroline Hayward
Aki S Havulinna
Nicholas D Hastie
Tamara B Harris
Talin Haritunians
Alistair S Hall
Ulf Gyllensten
Candace Guiducci
Leif C Groop
Elena Gonzalez
Christian Gieger
Nelson B Freimer
Luigi Ferrucci
Jeanette Erdmann
Paul Elliott
Kenechi G Ejebe
Angela Döring
Anna F Dominiczak
Serkalem Demissie
Panagiotis Deloukas
Eco J C de Geus
Ulf de Faire
Gabriel Crawford
Francis S Collins
Yii-der I Chen
Mark J Caulfield
Harry Campbell
Noel P Burtt
Lori L Bonnycastle
Dorret I Boomsma
S Matthijs Boekholdt
Richard N Bergman
Inês Barroso
Stefania Bandinelli
Christie M Ballantyne
Themistocles L Assimes
Thomas Quertermous
David Altshuler
Mark Seielstad
Tien Y Wong
E-Shyong Tai
Alan B Feranil
Christopher W Kuzawa
Linda S Adair
Herman A Taylor
Ingrid B Borecki
Stacey B Gabriel
James G Wilson
Hilma Holm
Unnur Thorsteinsdottir
Vilmundur Gudnason
Ronald M Krauss
Karen L Mohlke
Jose M Ordovas
Patricia B Munroe
Jaspal S Kooner
Alan R Tall
Robert A Hegele
John J P Kastelein
Eric E Schadt
Jerome I Rotter
Eric Boerwinkle
David P Strachan
Vincent Mooser
Kari Stefansson
Muredach P Reilly
Nilesh J Samani
Heribert Schunkert
L Adrienne Cupples
Manjinder S Sandhu
Paul M Ridker
Daniel J Rader
Cornelia M van Duijn
Leena Peltonen
Gonçalo R Abecasis
Michael Boehnke
Sekar Kathiresan
Broad Institute · USErasmus MC · NLUniversity of Helsinki · FINational Institutes of Health · USAddenbrooke's Hospital · GBCedars-Sinai Medical Center · USTranslational Therapeutics (United States) · USUniversity of Michigan · USdeCODE Genetics (Iceland) · ISEurac Research · ITGlaxoSmithKline (United States) · USHelmholtz Zentrum München · DEImperial College London · GBInstitute of Genetics and Cancer · GBKarolinska Institutet · SEKorea National Institute of Health · KRUniversity of Cambridge · GBUniversity of Lübeck · DEUniversity of North Carolina at Chapel Hill · USUniversity of Washington · US
Funding
Institute for Clinical and Translational Research (UL1)UL1RR025005 · NCRR · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2007 to 2011
$75.8MZONA-FREE HAMSTER OVA ASSAY AS AN INDICATOR OF MALE FERTILITYM01RR000425 · NCRR · LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER · PI ANDERSON, GAIL V · 1985 to 2011
$74.2MType 1 Diabetes Genetics ConsortiumU01DK062418 · NIDDK · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI RICH, STEPHEN S. · 2002 to 2007
$59.8MTransgenic & Knock-out MouseP30DK063491 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI PETER J TONTONOZ · 2003 to 2026
$40.4MUNC-CH CENTER FOR ENVIRONMENTAL HEALTH &SUSCEPTIBILITYP30ES010126 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Melissa A. Troester · 2001 to 2026
$36.3MUNIV OF NORTH CAROLINA CLINICAL NUTRITION RESEARCH UNITP30DK056350 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SUSAN M. SMITH · 1999 to 2026
$31.6MWomen's Health Study: Continued Follow-upR01CA047988 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI BURING, JULIE E., LEE, I-MIN · 1991 to 2014
$28.2MBuilding on GWAS for NHLBI-disease: the CHARGE consortiumRC2HL102419 · NHLBI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI BOERWINKLE, ERIC A. · 2009 to 2010
$27.6MPharmacogenomics and Risk of Cardiovascular DiseaseU01HL069757 · NHLBI · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI KRAUSS, RONALD M · 2001 to 2009
$24.7MGenome-Wide Association Analysis in Essential Hypertension (FEHGAS study)R01HL086694 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI ARAVINDA CHAKRAVARTI · 2007 to 2026
$21.2MUniversity of Michigan Training Program in Genomic ScienceT32HG000040 · NHGRI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Sebastian Zoellner · 1995 to 2026
$16.4MMULTIDISCIPLINARY RESEARCH TRAINING IN CARDIOLOGYT32HL007208 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI Patrick Thomas Ellinor, David E Sosnovik · 1985 to 2026
$16.1MBritish Heart Foundation PG/02/128British Heart Foundation PG/08/094British Heart Foundation PG/08/094/26019British Heart Foundation RG/07/005/23633British Heart Foundation SP/08/005/25115Chief Scientist Office CZB/4/710FIC NIH HHS TW05596Intramural NIH HHSMedical Research Council G0000934Medical Research Council G0401527Medical Research Council G0601966Medical Research Council G0700931Medical Research Council G0701863Medical Research Council G0801056Medical Research Council G0801566Medical Research Council G9521010Medical Research Council G9521010DMedical Research Council MC_QA137934Medical Research Council MC_U106179471Medical Research Council MC_U106188470Medical Research Council MC_U127561128NCI NIH HHS CA 047988NCRR NIH HHS M01-RR00425NCRR NIH HHS RR20649NCRR NIH HHS U54 RR020278NCRR NIH HHS UL1RR025005NHGRI NIH HHS 1Z01 HG000024NHGRI NIH HHS N01-HG-65403NHGRI NIH HHS T32 HG000040NHGRI NIH HHS T32 HG00040NHGRI NIH HHS U01HG004402NHLBI NIH HHS 5R01HL087679-02NHLBI NIH HHS 5R01HL08770003NHLBI NIH HHS 5R01HL08821502NHLBI NIH HHS HL 04381NHLBI NIH HHS HL 080467NHLBI NIH HHS HL085144NHLBI NIH HHS HL-54776NHLBI NIH HHS K99HL094535NHLBI NIH HHS K99 HL098364NHLBI NIH HHS N01 HC-15103NHLBI NIH HHS N01-HC-25195NHLBI NIH HHS N01-HC-35129NHLBI NIH HHS N01-HC-45133NHLBI NIH HHS N01-HC-55015NHLBI NIH HHS N01-HC-55016NHLBI NIH HHS N01-HC-55018NHLBI NIH HHS N01-HC-55019NHLBI NIH HHS N01-HC-55020NHLBI NIH HHS N01-HC-55021NHLBI NIH HHS N01-HC-55022NHLBI NIH HHS N01 HC-55222NHLBI NIH HHS N01-HC-75150NHLBI NIH HHS N01-HC-85079NHLBI NIH HHS N01-HC-85080NHLBI NIH HHS N01-HC-85081NHLBI NIH HHS N01-HC-85082NHLBI NIH HHS N01-HC-85083NHLBI NIH HHS N01-HC-85084NHLBI NIH HHS N01-HC-85085NHLBI NIH HHS N01-HC-85086NHLBI NIH HHS N02-HL-6-4278NHLBI NIH HHS R01HL086694NHLBI NIH HHS R01HL087641NHLBI NIH HHS R01HL087652NHLBI NIH HHS R01 HL087676NHLBI NIH HHS R01 HL089309NHLBI NIH HHS R01 HL089650NHLBI NIH HHS R01HL59367NHLBI NIH HHS RC1 HL099634NHLBI NIH HHS RC1 HL099793NHLBI NIH HHS RC2 HL101864,NHLBI NIH HHS RC2 HL102419NHLBI NIH HHS T32HL007208NHLBI NIH HHS U01 HL069757NHLBI NIH HHS U01 HL080295NIA NIH HHS N01-AG-12100NICHD NIH HHS R24 HD050924NIDDK NIH HHS 5R01DK06833603NIDDK NIH HHS 5R01DK07568102NIDDK NIH HHS DK062370NIDDK NIH HHS DK063491NIDDK NIH HHS DK072193NIDDK NIH HHS DK078150NIDDK NIH HHS DK56350NIDDK NIH HHS R01 DK072193NIDDK NIH HHS R01 DK078150NIDDK NIH HHS U01 DK062370NIDDK NIH HHS U01 DK062418NIEHS NIH HHS ES10126NIGMS NIH HHS T32 GM007092PHS HHS HHSN268200625226CWellcome Trust 068545/Z/02Wellcome Trust 076113/B/04/ZWellcome Trust 077016/Z/05/ZWellcome Trust 079895
Abstract
Plasma concentrations of total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol and triglycerides are among the most important risk factors for coronary artery disease (CAD) and are targets for therapeutic intervention. We screened the genome for common variants associated with plasma lipids in >100,000 individuals of European ancestry. Here we report 95 significantly associated loci (P < 5 x 10(-8)), with 59 showing genome-wide significant association with lipid traits for the first time. The newly reported associations include single nucleotide polymorphisms (SNPs) near known lipid regulators (for example, CYP7A1, NPC1L1 and SCARB1) as well as in scores of loci not previously implicated in lipoprotein metabolism. The 95 loci contribute not only to normal variation in lipid traits but also to extreme lipid phenotypes and have an impact on lipid traits in three non-European populations (East Asians, South Asians and African Americans). Our results identify several novel loci associated with plasma lipids that are also associated with CAD. Finally, we validated three of the novel genes-GALNT2, PPP1R3B and TTC39B-with experiments in mouse models. Taken together, our findings provide the foundation to develop a broader biological understanding of lipoprotein metabolism and to identify new therapeutic opportunities for the prevention of CAD.
Indexed as
Genome-Wide Association StudyAnimalsAsian PeopleBlack or African AmericanCholesterol, HDLCholesterol, LDLCoronary Artery DiseaseEuropeFemaleGenetic LociGenotypeHumansLipid MetabolismLipidsLiverMaleCholesterol, HDLCholesterol, LDLLipidsN-AcetylgalactosaminyltransferasesPolypeptide N-acetylgalactosaminyltransferasePpp1r3b protein, mouseProtein Phosphatase 1Triglycerides
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