ArticleThe Journal of investigative dermatology2010
Hypoxia impairs skin myofibroblast differentiation and function.
Article in The Journal of investigative dermatology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
40 citing papers in PubMed.
- Perioperative hyperbaric oxygen therapy: mechanisms, evidence, and clinical application.Medical gas research · 2027Review
- Microneedle-guided monitoring and therapy in chronic limb-threatening ischemia.Frontiers in cell and developmental biology · 2026Review
- CD9 promotes TβR2-TβR1 association driving the transition of human dermal fibroblasts to myofibroblast under hypoxia.Molecular medicine (Cambridge, Mass.) · 2024Article
- Direct cellular reprogramming and transdifferentiation of fibroblasts on wound healing-Fantasy or reality?Chronic diseases and translational medicine · 2023Review
- The Role of Myofibroblasts in Physiological and Pathological Tissue Repair.Cold Spring Harbor perspectives in biology · 2023Review
- Canadian Contributions in Fibroblast Biology.Cells · 2022Review
- [Regulatory effects of bio-intensity electric field on transformation of human skin fibroblasts].Zhonghua shao shang yu chuang mian xiu fu za zhi · 2022Article
- Review
- Hyperbaric oxygen influences chronic wound healing - a cellular level review.Physiological research · 2021Review
- Decreased Choroidal Blood Perfusion Induces Myopia in Guinea Pigs.Investigative ophthalmology & visual science · 2021Article
- Hypoxia induces stress fiber formation in adipocytes in the early stage of obesity.Scientific reports · 2021Article
- Histatin 1 enhanced the speed and quality of wound healing through regulating the behaviour of fibroblast.Cell proliferation · 2021Article
- Decreased Substrate Stiffness Promotes a Hypofibrotic Phenotype in Cardiac Fibroblasts.International journal of molecular sciences · 2021Article
- Agent-based model provides insight into the mechanisms behind failed regeneration following volumetric muscle loss injury.PLoS computational biology · 2021Article
- Myofibroblast Markers and Microscopy Detection Methods in Cell Culture and Histology.Methods in molecular biology (Clifton, N.J.) · 2021Article
- Quantifying cellular forces: Practical considerations of traction force microscopy for dermal fibroblasts.Experimental dermatology · 2021Review
- Distinct differences in hypoxic responses between human oral mucosa and skin fibroblasts in a 3D collagen matrix.In vitro cellular & developmental biology. Animal · 2020Article
- Engineered Biomaterial Platforms to Study Fibrosis.Advanced healthcare materials · 2020Review
- Type I Collagen Suspension Induces Neocollagenesis and Myodifferentiation in FibroblastsBioMed research international · 2020Article
- Non-invasive imaging in dermatology and the unique potential of raster-scan optoacoustic mesoscopy.Journal of the European Academy of Dermatology and Venereology : JEADV · 2019Review
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Authors and funding
6 authors.
Funding
Abstract
Ischemic wounds are characterized by oxygen levels lower than that of healthy skin (hypoxia) and poor healing. To better understand the pathophysiology of impaired wound healing, we investigated how switching from high (21%) to low (2%) oxygen levels directly affects cultured skin myofibroblasts, essential cells for the normal wound repair process. Myofibroblast differentiation and function were assessed by quantifying α-smooth muscle actin expression and cell contraction in collagen gels and on wrinkling silicone substrates. Culture for 5 days at 2% oxygen is perceived as hypoxia and significantly reduced myofibroblast differentiation and contraction despite high levels of the profibrotic transforming growth factor-β1. Analysis of α-smooth muscle actin expression on wrinkling substrates over time showed that reduced myofibroblast contraction preceded α-smooth muscle actin disassembly from stress fibers after switching from 21 to 2% oxygen. These effects were reversible by restoring high oxygen conditions and by applying mechanical stress. We suggest that mechanical challenge is a clinical relevant strategy to improve ischemic and chronic wound healing by supporting myofibroblast formation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.