ArticleJournal of clinical microbiology2010
Is repeat PCR needed for diagnosis of Clostridium difficile infection?
Article in Journal of clinical microbiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 4 syntheses or guidelines pooled it, 73 citations in OpenAlex.
- A Laboratory Medicine Best Practices Systematic Review and Meta-analysis of Nucleic Acid Amplification Tests (NAATs) and Algorithms Including NAATs for the Diagnosis ofClinical microbiology reviews · 2019Pooled it
- A Guide to Utilization of the Microbiology Laboratory for Diagnosis of Infectious Diseases: 2018 Update by the Infectious Diseases Society of America and the American Society for Microbiology.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2018Guideline
- A guide to utilization of the microbiology laboratory for diagnosis of infectious diseases: 2013 recommendations by the Infectious Diseases Society of America (IDSA) and the American Society for Microbiology (ASM)(a).Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2013Guideline
- Molecular techniques for diagnosis of Clostridium difficile infection: systematic review and meta-analysis.Mayo Clinic proceedings · 2012Pooled it
- Diagnostic Guidance for C. difficile Infections.Advances in experimental medicine and biology · 2024Article
- Clinical Outcomes of Treated and Untreated C. difficile PCR-Positive/Toxin-Negative Adult Hospitalized Patients: a Quasi-Experimental Noninferiority Study.Journal of clinical microbiology · 2022Article
- Diagnostic Stewardship as a Team Sport: Interdisciplinary Perspectives on Improved Implementation of Interventions and Effect Measurement.Antibiotics (Basel, Switzerland) · 2022Review
- Physical, Laboratory, Radiographic, and Endoscopic Workup forClinics in colon and rectal surgery · 2020Review
- The Role of Diagnostic Stewardship inCurrent infectious disease reports · 2020Article
- South African Society of Clinical MicrobiologySouthern African journal of infectious diseases · 2020Article
- Is Follow-Up Testing with the FilmArray Gastrointestinal Multiplex PCR Panel Necessary?Journal of clinical microbiology · 2017Article
- Lack of Association Between the Clinical Outcome ofGastroenterology research · 2017Article
- Current knowledge on the laboratory diagnosis ofWorld journal of gastroenterology · 2017Review
- Clostridium Difficile Infection from a Surgical Perspective.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2015Review
- Characteristics and Antibiotic Use Associated With Short-Term Risk of Clostridium difficile Infection Among Hospitalized Patients.American journal of clinical pathology · 2015Article
- Adherence to and Outcomes Associated with a Clostridium difficile Guideline at a Large Teaching Institution.Hospital pharmacy · 2015Article
- Clinical characteristics of patients who test positive for Clostridium difficile by repeat PCR.Journal of clinical microbiology · 2014Article
- Impact of changes in Clostridium difficile testing practices on stool rejection policies and C. difficile positivity rates across multiple laboratories in the United States.Journal of clinical microbiology · 2014Article
- Economic evaluation of laboratory testing strategies for hospital-associated Clostridium difficile infection.Journal of clinical microbiology · 2014Article
- Effect of nucleic acid amplification testing on population-based incidence rates of Clostridium difficile infection.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Patients with diarrhea, defined as loose or watery stool, and two or more Clostridium difficile tcdB PCR tests within 14 days of each other were investigated. Repeat PCR for 293 patients with a prior negative result yielded negative results in 396 (97.5%) of 406 tests. Ten new positives were detected, including one false positive. Repeat PCR within 7 days appears rarely useful, except for patients with evidence of a new infection.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.